ATM
Gene Ontology Biological Process
- DNA damage checkpoint [IMP]
- DNA damage induced protein phosphorylation [ISO]
- DNA repair [IDA, IMP]
- V(D)J recombination [IGI]
- brain development [IGI]
- cell cycle arrest [ISO]
- cellular response to DNA damage stimulus [ISO, TAS]
- cellular response to gamma radiation [ISO]
- double-strand break repair via homologous recombination [IBA]
- female gamete generation [IMP]
- heart development [IGI]
- histone mRNA catabolic process [ISO]
- histone phosphorylation [ISO]
- histone-serine phosphorylation [ISO]
- intrinsic apoptotic signaling pathway in response to DNA damage [IGI, IMP]
- lipoprotein catabolic process [IGI]
- mitotic spindle assembly checkpoint [ISO]
- negative regulation of B cell proliferation [ISO]
- neuron apoptotic process [IGI]
- oocyte development [IMP]
- peptidyl-serine phosphorylation [ISO]
- phosphatidylinositol phosphorylation [ISO]
- phosphatidylinositol-3-phosphate biosynthetic process [ISO]
- positive regulation of DNA damage response, signal transduction by p53 class mediator [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of neuron apoptotic process [IGI]
- pre-B cell allelic exclusion [IMP]
- protein autophosphorylation [ISO]
- protein phosphorylation [IDA, ISO, TAS]
- regulation of cell cycle [ISO]
- replicative senescence [ISO]
- response to hypoxia [ISO]
- response to ionizing radiation [IGI, ISO]
- signal transduction involved in mitotic G2 DNA damage checkpoint [ISO]
- somitogenesis [IGI]
Gene Ontology Molecular Function- 1-phosphatidylinositol-3-kinase activity [ISO]
- DNA-dependent protein kinase activity [ISO]
- histone serine kinase activity [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein dimerization activity [IBA, ISO]
- protein kinase activity [IDA, TAS]
- protein serine/threonine kinase activity [ISO]
- 1-phosphatidylinositol-3-kinase activity [ISO]
- DNA-dependent protein kinase activity [ISO]
- histone serine kinase activity [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein dimerization activity [IBA, ISO]
- protein kinase activity [IDA, TAS]
- protein serine/threonine kinase activity [ISO]
DYNLL1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
ATM loss disrupts the autophagy-lysosomal pathway.
ATM (ataxia telangiectasia mutated) protein is found associated with multiple organelles including synaptic vesicles, endosomes and lysosomes, often in cooperation with ATR (ataxia telangiectasia and Rad3 related). Mutation of the ATM gene results in ataxia-telangiectasia (A-T), an autosomal recessive disorder with defects in multiple organs including the nervous system. Precisely how ATM deficiency leads to the complex phenotypes of A-T, ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID