BTRC
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [TAS]
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [IBA]
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [TAS]
- mitotic cell cycle [TAS]
- negative regulation of sequence-specific DNA binding transcription factor activity [TAS]
- negative regulation of smoothened signaling pathway [TAS]
- negative regulation of transcription, DNA-templated [IMP]
- positive regulation of circadian rhythm [ISS]
- positive regulation of proteolysis [IMP]
- positive regulation of transcription, DNA-templated [ISS]
- positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IDA]
- protein dephosphorylation [ISS]
- protein destabilization [IMP]
- protein ubiquitination [IDA]
- regulation of circadian rhythm [IDA]
- regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
- signal transduction [TAS]
- ubiquitin-dependent protein catabolic process [IDA]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MAPK13
Gene Ontology Biological Process
- MAPK cascade [IDA]
- Ras protein signal transduction [TAS]
- intracellular signal transduction [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-serine phosphorylation [IDA]
- positive regulation of inflammatory response [IC]
- positive regulation of interleukin-6 production [IMP]
- response to osmotic stress [IDA]
- response to stress [IDA]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
F-box Protein ?TrCP1 Is a Substrate of Extracellular Signal-regulated Kinase 2.
F-box proteins, consisting of 69 members which are organized into the three subclasses FBXW, FBXL, and FBXO, are the substrate specific recognition subunits of the SKP1-Cullin 1-F-box protein E3 ligase complex. Although ?TrCP 1 and 2, members of the FBXW subfamily, are known to regulate some protein stability, molecular mechanisms by which these proteins can recognize proper substrates are unknown. ... [more]
Throughput
- Low Throughput
Additional Notes
- Source of BTRC not clear
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MAPK13 BTRC | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | 3325311 |
Curated By
- BioGRID