BAIT

TDRD3

RP11-459E2.1
tudor domain containing 3
GO Process (1)
GO Function (4)
GO Component (2)
Homo sapiens
PREY

UBC

HMG20
ubiquitin C
GO Process (75)
GO Function (3)
GO Component (6)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Homo sapiens

Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Publication

TDRD3 promotes DHX9 chromatin recruitment and R-loop resolution.

Yuan W, Al-Hadid Q, Wang Z, Shen L, Cho H, Wu X, Yang Y

R-loops, which consist of a DNA/RNA hybrid and a displaced single-stranded DNA (ssDNA), are increasingly recognized as critical regulators of chromatin biology. R-loops are particularly enriched at gene promoters, where they play important roles in regulating gene expression. However, the molecular mechanisms that control promoter-associated R-loops remain unclear. The epigenetic 'reader' Tudor domain-containing protein 3 (TDRD3), which recognizes methylarginine marks ... [more]

Nucleic Acids Res Dec. 07, 2020; 49(15);8573-8591 [Pubmed: 34329467]

Throughput

  • Low Throughput

Additional Notes

  • #LPPI
  • Likely protein-protein interaction
  • Source of TDRD3 not clear

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
UBC TDRD3
Reconstituted Complex
Reconstituted Complex

An interaction is detected between purified proteins in vitro.

High-BioGRID
2881122

Curated By

  • BioGRID