BAIT

CDCP1

CD318, SIMA135, TRASK, UNQ2486/PRO5773
CUB domain containing protein 1
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY

HSPA4

APG-2, HEL-S-5a, HS24/P52, HSPH2, RY, hsp70, hsp70RY
heat shock 70kDa protein 4
GO Process (3)
GO Function (1)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Inhibition of cotranslational translocation by apratoxin S4: Effects on oncogenic receptor tyrosine kinases and the fate of transmembrane proteins produced in the cytoplasm.

Cai W, Ratnayake R, Wang M, Chen QY, Raisch KP, Dang LH, Law BK, Luesch H

Receptor tyrosine kinases (RTKs) have become major targets for anticancer therapy. However, resistance and signaling pathway redundancy has been problematic. The marine-derived apratoxins act complementary to direct kinase inhibitors by downregulating the levels of multiple of these receptors and additionally prevent the secretion of growth factors that act on these receptors by targeting Sec61?, therefore interfering with cotranslational translocation. We ... [more]

Curr Res Pharmacol Drug Discov Dec. 16, 2021; 2();100053 [Pubmed: 34909679]

Throughput

  • High Throughput

Curated By

  • BioGRID