TRIM27
Gene Ontology Biological Process
- Arp2/3 complex-mediated actin nucleation [ISO]
- innate immune response [IDA, ISO]
- interferon-gamma secretion [ISO]
- negative regulation of adaptive immune response [ISO]
- negative regulation of calcium ion import [ISO]
- negative regulation of gene expression, epigenetic [ISO]
- negative regulation of interleukin-2 secretion [ISO]
- negative regulation of protein kinase activity [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IGI, ISO]
- negative regulation of tumor necrosis factor production [ISO]
- negative regulation of viral release from host cell [IDA]
- negative regulation of viral transcription [IDA, ISO]
- positive regulation of actin nucleation [IGI]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- protein K63-linked ubiquitination [ISO]
- protein trimerization [ISO]
- retrograde transport, endosome to Golgi [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
TBK1
Gene Ontology Biological Process
- activation of innate immune response [IMP]
- defense response to Gram-positive bacterium [IMP]
- dendritic cell proliferation [IGI]
- negative regulation of gene expression [IMP]
- positive regulation of interferon-alpha production [ISO]
- positive regulation of interferon-beta biosynthetic process [IMP]
- positive regulation of interferon-beta production [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
A novel lncRNA linc-AhRA negatively regulates innate antiviral response in murine microglia upon neurotropic herpesvirus infection.
Microglia are the primary cellular source of type I interferons (I-IFNs) in the brain upon neurotropic virus infection. Although the I-IFN-based antiviral innate immune response is crucial for eliminating viruses, overproduction led to immune disorders. Therefore, the relatively long-lasting I-IFNs must be precisely controlled, but the regulatory mechanism for the innate antiviral response in microglia remains largely unknown. Long non-coding ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID