MRE11A
Gene Ontology Biological Process
- DNA catabolic process, endonucleolytic [TAS]
- DNA duplex unwinding [IMP]
- DNA recombination [TAS]
- DNA repair [TAS]
- base-excision repair [IBA]
- cellular response to DNA damage stimulus [IDA]
- double-strand break repair [IBA, TAS]
- double-strand break repair via homologous recombination [TAS]
- double-strand break repair via nonhomologous end joining [TAS]
- innate immune response [TAS]
- intra-S DNA damage checkpoint [IBA]
- negative regulation of DNA endoreduplication [IMP]
- nucleic acid phosphodiester bond hydrolysis [IBA, TAS]
- nucleotide-excision repair [IBA]
- positive regulation of kinase activity [IDA]
- positive regulation of protein autophosphorylation [IDA]
- positive regulation of type I interferon production [TAS]
- reciprocal meiotic recombination [TAS]
- regulation of mitotic recombination [TAS]
- sister chromatid cohesion [IMP]
- telomere maintenance [IBA]
- telomere maintenance via telomerase [TAS]
Gene Ontology Molecular Function- 3'-5' exonuclease activity [IBA]
- ATP-dependent DNA helicase activity [IMP]
- DNA binding [IDA]
- double-stranded DNA binding [TAS]
- endodeoxyribonuclease activity [TAS]
- endonuclease activity [IBA]
- nuclease activity [TAS]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- single-stranded DNA endodeoxyribonuclease activity [TAS]
- 3'-5' exonuclease activity [IBA]
- ATP-dependent DNA helicase activity [IMP]
- DNA binding [IDA]
- double-stranded DNA binding [TAS]
- endodeoxyribonuclease activity [TAS]
- endonuclease activity [IBA]
- nuclease activity [TAS]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- single-stranded DNA endodeoxyribonuclease activity [TAS]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
GRB2 enforces homology-directed repair initiation by MRE11.
DNA double-strand break (DSB) repair is initiated by MRE11 nuclease for both homology-directed repair (HDR) and alternative end joining (Alt-EJ). Here, we found that GRB2, crucial to timely proliferative RAS/MAPK pathway activation, unexpectedly forms a biophysically validated GRB2-MRE11 (GM) complex for efficient HDR initiation. GRB2-SH2 domain targets the GM complex to phosphorylated H2AX at DSBs. GRB2 K109 ubiquitination by E3 ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID