BAIT

C5ORF51

chromosome 5 open reading frame 51
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY

CCZ1B

C7orf28B, H_NH0577018.2
CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
GO Process (1)
GO Function (0)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Cellular Component

Homo sapiens

Affinity Capture-Western

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.

Publication

C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.

Yan BR, Li T, Coyaud E, Laurent EMN, St-Germain J, Zhou Y, Kim PK, Raught B, Brumell JH

Depolarized mitochondria can be degraded via mitophagy, a selective form of autophagy. The RAB GTPase RAB7A was recently shown to play a key role in this process. RAB7A regulates late endocytic trafficking under normal growth conditions but is translocated to the mitochondrial surface following depolarization. However, how RAB7A activity is regulated during mitophagy is not understood. Here, using a proximity-dependent ... [more]

Autophagy Aug. 25, 2021; ();1-12 [Pubmed: 34432599]

Throughput

  • Low Throughput

Curated By

  • BioGRID