BAIT
LGALS8
Gal-8, PCTA-1, PCTA1, Po66-CBP, RP11-385F5.1
lectin, galactoside-binding, soluble, 8
GO Process (0)
GO Function (1)
GO Component (3)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
P4HB
DSI, ERBA2L, GIT, P4Hbeta, PDI, PDIA1, PHDB, PO4DB, PO4HB, PROHB
prolyl 4-hydroxylase, beta polypeptide
GO Process (8)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
- cellular response to hypoxia [IMP]
- extracellular matrix organization [TAS]
- lipoprotein metabolic process [TAS]
- peptidyl-proline hydroxylation to 4-hydroxy-L-proline [IDA]
- protein folding [IBA]
- regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [IMP]
- response to endoplasmic reticulum stress [IMP]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Galectin-8 Senses Phagosomal Damage and Recruits Selective Autophagy Adapter TAX1BP1 To Control Mycobacterium tuberculosis Infection in Macrophages.
Mycobacterium tuberculosis (Mtb) causes one of the deadliest infectious diseases worldwide. Upon infection, Mtb is phagocytosed by macrophages and uses its virulence-associated ESX-1 secretion system to modulate the host cell. We showed previously that the ESX-1 secretion system perturbs the Mtb-containing phagosome, and a population (?30%) of intracellular Mtb is tagged with ubiquitin and targeted to selective autophagy. However, our ... [more]
mBio Dec. 31, 2020; 12(4);e0187120 [Pubmed: 34225486]
Throughput
- Low Throughput
Curated By
- BioGRID