TLE1
Gene Ontology Biological Process
- Notch signaling pathway [TAS]
- multicellular organismal development [TAS]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- negative regulation of Wnt signaling pathway [NAS]
- negative regulation of anoikis [IMP]
- negative regulation of transcription, DNA-templated [IDA]
- organ morphogenesis [TAS]
- positive regulation of gene expression [IMP]
- signal transduction [TAS]
Gene Ontology Molecular Function
PIN1
Gene Ontology Biological Process
- cytokine-mediated signaling pathway [TAS]
- innate immune response [TAS]
- negative regulation of ERK1 and ERK2 cascade [IDA]
- negative regulation of cell motility [IDA]
- negative regulation of transforming growth factor beta receptor signaling pathway [IDA]
- negative regulation of type I interferon production [TAS]
- positive regulation of Rho GTPase activity [IMP]
- positive regulation of protein phosphorylation [IGI]
- positive regulation of ubiquitin-protein transferase activity [IDA]
- protein peptidyl-prolyl isomerization [IDA]
- regulation of cytokinesis [IGI, IMP]
- regulation of mitosis [TAS]
- regulation of pathway-restricted SMAD protein phosphorylation [IDA]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Prolyl isomerase Pin1 and protein kinase HIPK2 cooperate to promote cortical neurogenesis by suppressing Groucho/TLE:Hes1-mediated inhibition of neuronal differentiation.
The Groucho/transducin-like Enhancer of split 1 (Gro/TLE1):Hes1 transcriptional repression complex acts in cerebral cortical neural progenitor cells to inhibit neuronal differentiation. The molecular mechanisms that regulate the anti-neurogenic function of the Gro/TLE1:Hes1 complex during cortical neurogenesis remain to be defined. Here we show that prolyl isomerase Pin1 (peptidyl-prolyl cis-trans isomerase NIMA-interacting 1) and homeodomain-interacting protein kinase 2 (HIPK2) are expressed ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PIN1 TLE1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID