BAIT

APOL3

APOLIII, CG121
apolipoprotein L, 3
GO Process (3)
GO Function (2)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

GBP1

guanylate binding protein 1, interferon-inducible
GO Process (2)
GO Function (1)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Phenotypic Enhancement

A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

A human apolipoprotein L with detergent-like activity kills intracellular pathogens.

Gaudet RG, Zhu S, Halder A, Kim BH, Bradfield CJ, Huang S, Xu D, Maminska A, Nguyen TN, Lazarou M, Karatekin E, Gupta K, MacMicking JD

Activation of cell-autonomous defense by the immune cytokine interferon-? (IFN-?) is critical to the control of life-threatening infections in humans. IFN-? induces the expression of hundreds of host proteins in all nucleated cells and tissues, yet many of these proteins remain uncharacterized. We screened 19,050 human genes by CRISPR-Cas9 mutagenesis and identified IFN-?-induced apolipoprotein L3 (APOL3) as a potent bactericidal ... [more]

Science Dec. 16, 2020; 373(6552); [Pubmed: 34437126]

Throughput

  • Low Throughput

Ontology Terms

  • disease: bacterial infectious disease (DOID:104)

Curated By

  • BioGRID