BAIT

NSP8

ORF1ab, ORF1ab-nsp8, SARS-CoV2 nsp8, SARS-CoV-2 nsp8, R1AB_SARS2, PRO_0000449626, GU280_gp01_nsp8
Non-structural protein 8
COVID-19 Coronavirus Project
GO Process (0)
GO Function (0)
GO Component (0)
Severe acute respiratory syndrome coronavirus 2
PREY

EXOSC8

CIP3, EAP2, OIP2, PCH1C, RRP43, Rrp43p, bA421P11.3, p9, RP11-421P11.3
exosome component 8
Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Low expression of EXOSC2 protects against clinical COVID-19 and impedes SARS-CoV-2 replication.

Moll T, Odon V, Harvey C, Collins MO, Peden A, Franklin J, Graves E, Marshall JN, Dos Santos Souza C, Zhang S, Castelli L, Hautbergue G, Azzouz M, Gordon D, Krogan N, Ferraiuolo L, Snyder MP, Shaw PJ, Rehwinkel J, Cooper-Knock J

New therapeutic targets are a valuable resource for treatment of SARS-CoV-2 viral infection. Genome-wide association studies have identified risk loci associated with COVID-19, but many loci are associated with comorbidities and are not specific to host-virus interactions. Here, we identify and experimentally validate a link between reduced expression of EXOSC2 and reduced SARS-CoV-2 replication. EXOSC2 was one of the 332 ... [more]

Life Sci Alliance Jan. 01, 2023; 6(1); [Pubmed: 36241425]

Throughput

  • High Throughput

Additional Notes

  • FDR<0.05
  • Strep-tagged Nsp8 co-expressed with untagged Nsp7

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
NSP8 EXOSC8
Affinity Capture-MS
Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

High0.9909BioGRID
2652537
NSP8 EXOSC8
Affinity Capture-MS
Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

High0.9909BioGRID
2875552

Curated By

  • BioGRID