BAIT

LGALS8

1200015E08Rik, AI326142, D13Ertd524e, Lgals-8
lectin, galactose binding, soluble 8
GO Process (2)
GO Function (1)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Mus musculus
PREY

TAX1BP1

CALCOCO3, T6BP, TXBP151, PRO0105
Tax1 (human T-cell leukemia virus type I) binding protein 1
Autophagy Project
UPS Project
GO Process (3)
GO Function (2)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Affinity Capture-Western

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.

Publication

Galectin-8 Senses Phagosomal Damage and Recruits Selective Autophagy Adapter TAX1BP1 To Control Mycobacterium tuberculosis Infection in Macrophages.

Bell SL, Lopez KL, Cox JS, Patrick KL, Watson RO

Mycobacterium tuberculosis (Mtb) causes one of the deadliest infectious diseases worldwide. Upon infection, Mtb is phagocytosed by macrophages and uses its virulence-associated ESX-1 secretion system to modulate the host cell. We showed previously that the ESX-1 secretion system perturbs the Mtb-containing phagosome, and a population (?30%) of intracellular Mtb is tagged with ubiquitin and targeted to selective autophagy. However, our ... [more]

mBio Dec. 31, 2020; 12(4);e0187120 [Pubmed: 34225486]

Throughput

  • Low Throughput

Curated By

  • BioGRID