BAIT
CLUH
1300001I01Rik, Kiaa0664, mKIAA0664, RP23-194P5.1
clustered mitochondria (cluA/CLU1) homolog
GO Process (2)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Mus musculus
PREY
PARK7
DJ-1, Dj1, RP23-272N19.5
Parkinson disease (autosomal recessive, early onset) 7
GO Process (19)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- adult locomotory behavior [IMP]
- cell proliferation [TAS]
- cellular response to hydrogen peroxide [IMP]
- cellular response to oxidative stress [IMP]
- cellular response to reactive oxygen species [IMP]
- dopamine uptake involved in synaptic transmission [IMP]
- hydrogen peroxide metabolic process [IMP]
- membrane depolarization [IMP]
- membrane hyperpolarization [IMP]
- mitochondrion organization [IMP]
- negative regulation of cell death [IMP]
- oxidation-reduction process [IMP]
- positive regulation of oxidative phosphorylation uncoupler activity [IMP]
- positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [IMP]
- positive regulation of reactive oxygen species biosynthetic process [IDA]
- protein stabilization [IMP]
- regulation of inflammatory response [IMP]
- response to hydrogen peroxide [IDA, IMP]
- synaptic transmission, dopaminergic [IMP]
Gene Ontology Molecular Function
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The interactome of CLUH reveals its association to SPAG5 and its co-translational proximity to mitochondrial proteins.
Mitochondria require thousands of proteins to fulfill their essential function in energy production and other fundamental biological processes. These proteins are mostly encoded by the nuclear genome, translated in the cytoplasm before being imported into the organelle. RNA binding proteins (RBPs) are central players in the regulation of this process by affecting mRNA translation, stability, or localization. CLUH is an ... [more]
BMC Biol Jan. 10, 2022; 20(1);13 [Pubmed: 35012549]
Throughput
- High Throughput
Additional Notes
- -BioID
- -fold change greater than 2 and a FDR < 0.1
Curated By
- BioGRID