BAIT
CLUH
1300001I01Rik, Kiaa0664, mKIAA0664, RP23-194P5.1
clustered mitochondria (cluA/CLU1) homolog
GO Process (2)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Mus musculus
PREY
CTTN
1110020L01Rik, Ems1
cortactin
GO Process (12)
GO Function (2)
GO Component (13)
Gene Ontology Biological Process
- actin cytoskeleton reorganization [ISO]
- cell motility [ISO]
- dendritic spine maintenance [IGI]
- focal adhesion assembly [ISO]
- intracellular protein transport [ISO]
- lamellipodium organization [ISO]
- negative regulation of extrinsic apoptotic signaling pathway [IGI]
- neuron projection morphogenesis [ISO]
- positive regulation of actin filament polymerization [ISO]
- receptor-mediated endocytosis [ISO]
- regulation of axon extension [ISO]
- substrate-dependent cell migration, cell extension [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- actin filament [ISO]
- cell cortex [IDA]
- cell junction [ISO]
- coated pit [ISO]
- cortical cytoskeleton [ISO]
- cytoplasm [IDA, ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- growth cone [ISO]
- lamellipodium [IDA, ISO]
- mitotic spindle midzone [IDA]
- ruffle [IDA]
- voltage-gated potassium channel complex [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The interactome of CLUH reveals its association to SPAG5 and its co-translational proximity to mitochondrial proteins.
Mitochondria require thousands of proteins to fulfill their essential function in energy production and other fundamental biological processes. These proteins are mostly encoded by the nuclear genome, translated in the cytoplasm before being imported into the organelle. RNA binding proteins (RBPs) are central players in the regulation of this process by affecting mRNA translation, stability, or localization. CLUH is an ... [more]
BMC Biol Jan. 10, 2022; 20(1);13 [Pubmed: 35012549]
Throughput
- High Throughput
Additional Notes
- -BioID
- -fold change greater than 2 and a FDR < 0.1
Curated By
- BioGRID