BAIT
RHOG
ARHG
ras homolog family member G
GO Process (14)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
- GTP catabolic process [IDA, TAS]
- Rac protein signal transduction [IDA]
- Rho protein signal transduction [IDA]
- actin cytoskeleton organization [IDA]
- activation of Rac GTPase activity [IMP]
- axon guidance [TAS]
- blood coagulation [TAS]
- cell chemotaxis [IMP]
- platelet activation [TAS]
- positive regulation of cell proliferation [TAS]
- positive regulation of establishment of protein localization to plasma membrane [IMP]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of small GTPase mediated signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
MAVS
CARDIF, IPS-1, IPS1, VISA
mitochondrial antiviral signaling protein
GO Process (23)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
- activation of innate immune response [IMP]
- cellular response to exogenous dsRNA [IMP]
- defense response to bacterium [IMP]
- defense response to virus [IDA]
- innate immune response [IMP, TAS]
- negative regulation of type I interferon production [TAS]
- negative regulation of viral genome replication [IDA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- positive regulation of IP-10 production [IDA]
- positive regulation of chemokine (C-C motif) ligand 5 production [IDA]
- positive regulation of defense response to virus by host [IDA, IMP]
- positive regulation of interferon-alpha production [IDA, IMP]
- positive regulation of interferon-beta production [IDA, IMP]
- positive regulation of interleukin-8 production [IDA]
- positive regulation of protein import into nucleus, translocation [IDA]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription factor import into nucleus [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of tumor necrosis factor production [IDA]
- positive regulation of type I interferon-mediated signaling pathway [IDA]
- regulation of peroxisome organization [IMP]
- signal transduction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms.
Guanine nucleotide exchange factors (RhoGEFs) and GTPase-activating proteins (RhoGAPs) coordinate the activation state of the Rho family of GTPases for binding to effectors. Here, we exploited proximity-dependent biotinylation to systematically define the Rho family proximity interaction network from 28 baits to produce 9,939 high-confidence proximity interactions in two cell lines. Exploiting the nucleotide states of Rho GTPases, we revealed the ... [more]
Nat. Cell Biol. Dec. 23, 2019; (); [Pubmed: 31871319]
Throughput
- High Throughput|Low Throughput
Additional Notes
- AvgP greater or equal to 0.95 assessed by SAINT express
- BioID
- RHOG WT bait, interaction in HEK293 cells
- RHOG wild type bait, interaction in Hela cells
- RHOG-G12V active mutant bait, interaction in HEK293 cells
- RHOG-G12V active mutant bait, interaction in Hela cells
Curated By
- BioGRID