BAIT
RHOC
ARH9, ARHC, H9, RHOH9, RP11-426L16.4
ras homolog family member C
GO Process (6)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
NOTCH2
AGS2, HJCYS, hN2
notch 2
GO Process (22)
GO Function (3)
GO Component (10)
Gene Ontology Biological Process
- Notch receptor processing [TAS]
- Notch signaling involved in heart development [IC]
- Notch signaling pathway [TAS]
- apoptotic process [TAS]
- atrial septum morphogenesis [IMP]
- bone remodeling [IMP]
- cell cycle arrest [IDA]
- cell fate determination [TAS]
- cell growth [IDA]
- gene expression [TAS]
- hemopoiesis [TAS]
- intracellular receptor signaling pathway [TAS]
- multicellular organismal development [NAS]
- negative regulation of apoptotic process [TAS]
- negative regulation of cell proliferation [IDA]
- nervous system development [NAS]
- organ morphogenesis [IEP]
- positive regulation of Ras protein signal transduction [IDA]
- pulmonary valve morphogenesis [IMP]
- regulation of transcription, DNA-templated [TAS]
- stem cell maintenance [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms.
Guanine nucleotide exchange factors (RhoGEFs) and GTPase-activating proteins (RhoGAPs) coordinate the activation state of the Rho family of GTPases for binding to effectors. Here, we exploited proximity-dependent biotinylation to systematically define the Rho family proximity interaction network from 28 baits to produce 9,939 high-confidence proximity interactions in two cell lines. Exploiting the nucleotide states of Rho GTPases, we revealed the ... [more]
Nat. Cell Biol. Dec. 23, 2019; (); [Pubmed: 31871319]
Throughput
- High Throughput|Low Throughput
Additional Notes
- AvgP greater or equal to 0.95 assessed by SAINT express
- BioID
- RHOC-G14V active mutant bait, interaction in HEK293 cells
- RHOC-G14V active mutant bait, interaction in Hela cells
Curated By
- BioGRID