BAIT
RHOA
ARH12, ARHA, RHO12, RHOH12
ras homolog family member A
GO Process (29)
GO Function (3)
GO Component (8)
Gene Ontology Biological Process
- GTP catabolic process [TAS]
- Rho protein signal transduction [TAS]
- actin cytoskeleton organization [TAS]
- apical junction assembly [IMP]
- apolipoprotein A-I-mediated signaling pathway [IMP]
- axon guidance [TAS]
- blood coagulation [TAS]
- cleavage furrow formation [IDA]
- negative chemotaxis [IMP]
- negative regulation of axonogenesis [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- ossification involved in bone maturation [ISS]
- phosphatidylinositol-mediated signaling [TAS]
- platelet activation [TAS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IEP]
- positive regulation of NF-kappaB import into nucleus [NAS]
- positive regulation of axonogenesis [TAS]
- positive regulation of cytokinesis [IMP]
- positive regulation of neuron differentiation [IMP]
- positive regulation of stress fiber assembly [IDA]
- regulation of axonogenesis [TAS]
- regulation of cell migration [IMP]
- regulation of osteoblast proliferation [ISS]
- regulation of small GTPase mediated signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
- spindle assembly involved in mitosis [IMP]
- substantia nigra development [IEP]
- trabecula morphogenesis [ISS]
- transforming growth factor beta receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SLC25A17
PMP34, RP3-362J20.2
solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17
GO Process (12)
GO Function (9)
GO Component (5)
Gene Ontology Biological Process
- ADP transport [IDA]
- AMP transport [IDA]
- ATP transport [IGI]
- FAD transmembrane transport [IDA]
- NAD transport [IDA]
- cellular lipid metabolic process [TAS]
- coenzyme A transmembrane transport [IDA]
- fatty acid alpha-oxidation [TAS]
- fatty acid beta-oxidation [IGI]
- fatty acid transport [IGI]
- nucleotide transmembrane transport [IDA]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function- ADP transmembrane transporter activity [IDA]
- AMP transmembrane transporter activity [IDA]
- ATP transmembrane transporter activity [IGI]
- FAD transmembrane transporter activity [IDA]
- FMN transmembrane transporter activity [IDA]
- NAD transporter activity [IDA]
- chaperone binding [IPI]
- coenzyme A transmembrane transporter activity [IDA]
- protein binding [IPI]
- ADP transmembrane transporter activity [IDA]
- AMP transmembrane transporter activity [IDA]
- ATP transmembrane transporter activity [IGI]
- FAD transmembrane transporter activity [IDA]
- FMN transmembrane transporter activity [IDA]
- NAD transporter activity [IDA]
- chaperone binding [IPI]
- coenzyme A transmembrane transporter activity [IDA]
- protein binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms.
Guanine nucleotide exchange factors (RhoGEFs) and GTPase-activating proteins (RhoGAPs) coordinate the activation state of the Rho family of GTPases for binding to effectors. Here, we exploited proximity-dependent biotinylation to systematically define the Rho family proximity interaction network from 28 baits to produce 9,939 high-confidence proximity interactions in two cell lines. Exploiting the nucleotide states of Rho GTPases, we revealed the ... [more]
Nat. Cell Biol. Dec. 23, 2019; (); [Pubmed: 31871319]
Throughput
- Low Throughput
Additional Notes
- AvgP greater or equal to 0.95 assessed by SAINT express
- BioID
- RHOA wild type bait, interaction in Hela cells
- RHOA-G14V active mutant bait, interaction in Hela cells
Curated By
- BioGRID