BAIT
RHOB
ARH6, ARHB, MST081, MSTP081, RHOH6
ras homolog family member B
GO Process (17)
GO Function (3)
GO Component (7)
Gene Ontology Biological Process
- GTP catabolic process [TAS]
- Rho protein signal transduction [TAS]
- apoptotic process [TAS]
- axon guidance [TAS]
- blood coagulation [TAS]
- cell adhesion [ISS]
- cellular response to hydrogen peroxide [IDA]
- cellular response to ionizing radiation [IDA]
- cytokinesis [IMP]
- endosome to lysosome transport [IDA]
- negative regulation of cell cycle [ISS]
- platelet activation [TAS]
- positive regulation of angiogenesis [ISS]
- positive regulation of apoptotic process [IMP]
- regulation of small GTPase mediated signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
- transformed cell apoptotic process [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ITGAV
CD51, MSK8, VNRA, VTNR
integrin, alpha V
GO Process (35)
GO Function (10)
GO Component (16)
Gene Ontology Biological Process
- ERK1 and ERK2 cascade [ISS]
- angiogenesis [IEP]
- antigen processing and presentation of exogenous peptide antigen via MHC class I [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [TAS]
- antigen processing and presentation of peptide antigen via MHC class I [TAS]
- apolipoprotein A-I-mediated signaling pathway [IMP]
- axon guidance [TAS]
- blood coagulation [TAS]
- calcium ion transmembrane transport [IDA]
- cell adhesion [IDA]
- cell growth [IMP]
- cell migration [IMP]
- cell-matrix adhesion [IDA, IMP, NAS]
- cell-substrate adhesion [IMP]
- endodermal cell differentiation [IMP]
- entry of symbiont into host cell by promotion of host phagocytosis [NAS]
- extracellular matrix organization [TAS]
- extrinsic apoptotic signaling pathway in absence of ligand [ISS]
- heterotypic cell-cell adhesion [IMP]
- integrin-mediated signaling pathway [NAS]
- leukocyte migration [TAS]
- negative chemotaxis [IMP]
- negative regulation of entry of bacterium into host cell [IDA]
- negative regulation of extrinsic apoptotic signaling pathway [IMP]
- negative regulation of lipid storage [IMP]
- negative regulation of lipid transport [IMP]
- negative regulation of lipoprotein metabolic process [IMP]
- negative regulation of low-density lipoprotein particle receptor biosynthetic process [IMP]
- negative regulation of macrophage derived foam cell differentiation [IMP]
- positive regulation of cell adhesion [IDA]
- positive regulation of cell proliferation [IDA]
- regulation of apoptotic cell clearance [ISS]
- regulation of phagocytosis [IDA]
- substrate adhesion-dependent cell spreading [IDA]
- viral entry into host cell [IMP, TAS]
Gene Ontology Molecular Function- extracellular matrix binding [IDA]
- extracellular matrix protein binding [IDA]
- fibronectin binding [IDA]
- insulin-like growth factor I binding [IDA]
- opsonin binding [ISS]
- protease binding [IDA]
- protein binding [IPI]
- protein kinase C binding [ISS]
- transforming growth factor beta binding [ISS]
- voltage-gated calcium channel activity [IDA]
- extracellular matrix binding [IDA]
- extracellular matrix protein binding [IDA]
- fibronectin binding [IDA]
- insulin-like growth factor I binding [IDA]
- opsonin binding [ISS]
- protease binding [IDA]
- protein binding [IPI]
- protein kinase C binding [ISS]
- transforming growth factor beta binding [ISS]
- voltage-gated calcium channel activity [IDA]
Gene Ontology Cellular Component
- alphav-beta3 integrin-IGF-1-IGF1R complex [IDA]
- cell surface [IDA, ISS]
- extracellular vesicular exosome [IDA]
- filopodium membrane [IDA]
- focal adhesion [IDA]
- integral component of plasma membrane [NAS]
- integrin alphav-beta3 complex [IDA]
- integrin alphav-beta5 complex [IDA]
- integrin alphav-beta8 complex [IDA]
- integrin complex [IDA, NAS]
- lamellipodium membrane [IDA]
- membrane [ISS]
- microvillus membrane [IDA]
- phagocytic vesicle [TAS]
- plasma membrane [IDA, TAS]
- ruffle membrane [IDA]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms.
Guanine nucleotide exchange factors (RhoGEFs) and GTPase-activating proteins (RhoGAPs) coordinate the activation state of the Rho family of GTPases for binding to effectors. Here, we exploited proximity-dependent biotinylation to systematically define the Rho family proximity interaction network from 28 baits to produce 9,939 high-confidence proximity interactions in two cell lines. Exploiting the nucleotide states of Rho GTPases, we revealed the ... [more]
Nat. Cell Biol. Dec. 23, 2019; (); [Pubmed: 31871319]
Throughput
- Low Throughput
Additional Notes
- AvgP greater or equal to 0.95 assessed by SAINT express
- BioID
- RHOB-G14V active mutant bait, interaction in Hela cells
Curated By
- BioGRID