BAIT
RHOB
ARH6, ARHB, MST081, MSTP081, RHOH6
ras homolog family member B
GO Process (17)
GO Function (3)
GO Component (7)
Gene Ontology Biological Process
- GTP catabolic process [TAS]
- Rho protein signal transduction [TAS]
- apoptotic process [TAS]
- axon guidance [TAS]
- blood coagulation [TAS]
- cell adhesion [ISS]
- cellular response to hydrogen peroxide [IDA]
- cellular response to ionizing radiation [IDA]
- cytokinesis [IMP]
- endosome to lysosome transport [IDA]
- negative regulation of cell cycle [ISS]
- platelet activation [TAS]
- positive regulation of angiogenesis [ISS]
- positive regulation of apoptotic process [IMP]
- regulation of small GTPase mediated signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
- transformed cell apoptotic process [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
JAG1
AGS, AHD, AWS, CD339, HJ1, JAGL1
jagged 1
GO Process (23)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
- Notch receptor processing [TAS]
- Notch signaling involved in heart development [IC, IMP]
- Notch signaling pathway [IMP, NAS, TAS]
- T cell mediated immunity [IMP]
- angiogenesis [NAS]
- aorta morphogenesis [ISS]
- cardiac neural crest cell development involved in outflow tract morphogenesis [ISS]
- cardiac right ventricle morphogenesis [ISS]
- cardiac septum morphogenesis [ISS]
- cell fate determination [NAS]
- endocardial cushion cell development [ISS]
- endothelial cell differentiation [NAS]
- hemopoiesis [NAS]
- keratinocyte differentiation [NAS]
- myoblast differentiation [NAS]
- negative regulation of stem cell differentiation [IMP]
- nervous system development [NAS]
- neuronal stem cell maintenance [IEP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- pulmonary artery morphogenesis [IMP]
- pulmonary valve morphogenesis [IMP]
- regulation of cell migration [NAS]
- regulation of cell proliferation [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms.
Guanine nucleotide exchange factors (RhoGEFs) and GTPase-activating proteins (RhoGAPs) coordinate the activation state of the Rho family of GTPases for binding to effectors. Here, we exploited proximity-dependent biotinylation to systematically define the Rho family proximity interaction network from 28 baits to produce 9,939 high-confidence proximity interactions in two cell lines. Exploiting the nucleotide states of Rho GTPases, we revealed the ... [more]
Nat. Cell Biol. Dec. 23, 2019; (); [Pubmed: 31871319]
Throughput
- Low Throughput
Additional Notes
- AvgP greater or equal to 0.95 assessed by SAINT express
- BioID
- RHOB-G14V active mutant bait, interaction in Hela cells
Curated By
- BioGRID