BAIT
RHOB
ARH6, ARHB, MST081, MSTP081, RHOH6
ras homolog family member B
GO Process (17)
GO Function (3)
GO Component (7)
Gene Ontology Biological Process
- GTP catabolic process [TAS]
- Rho protein signal transduction [TAS]
- apoptotic process [TAS]
- axon guidance [TAS]
- blood coagulation [TAS]
- cell adhesion [ISS]
- cellular response to hydrogen peroxide [IDA]
- cellular response to ionizing radiation [IDA]
- cytokinesis [IMP]
- endosome to lysosome transport [IDA]
- negative regulation of cell cycle [ISS]
- platelet activation [TAS]
- positive regulation of angiogenesis [ISS]
- positive regulation of apoptotic process [IMP]
- regulation of small GTPase mediated signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
- transformed cell apoptotic process [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ACVR1B
ACTRIB, ACVRLK4, ALK4, SKR2
activin A receptor, type IB
GO Process (14)
GO Function (11)
GO Component (4)
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [IDA]
- activin receptor signaling pathway [IDA, IMP]
- extrinsic apoptotic signaling pathway [IMP]
- negative regulation of cell growth [IDA]
- nodal signaling pathway [IGI]
- peptidyl-threonine phosphorylation [IDA]
- positive regulation of activin receptor signaling pathway [IDA]
- positive regulation of erythrocyte differentiation [IDA]
- positive regulation of trophoblast cell migration [IDA]
- protein autophosphorylation [IDA]
- protein phosphorylation [IDA]
- regulation of transcription, DNA-templated [IDA]
- signal transduction [IDA]
- transmembrane receptor protein serine/threonine kinase signaling pathway [TAS]
Gene Ontology Molecular Function- ATP binding [IDA]
- SMAD binding [IDA]
- activin binding [IDA]
- activin receptor activity, type I [IDA, TAS]
- activin-activated receptor activity [IDA]
- growth factor binding [IPI]
- inhibin binding [IPI]
- protein binding [IPI]
- protein serine/threonine kinase activity [EXP, IDA]
- transmembrane receptor protein serine/threonine kinase activity [NAS]
- ubiquitin protein ligase binding [NAS]
- ATP binding [IDA]
- SMAD binding [IDA]
- activin binding [IDA]
- activin receptor activity, type I [IDA, TAS]
- activin-activated receptor activity [IDA]
- growth factor binding [IPI]
- inhibin binding [IPI]
- protein binding [IPI]
- protein serine/threonine kinase activity [EXP, IDA]
- transmembrane receptor protein serine/threonine kinase activity [NAS]
- ubiquitin protein ligase binding [NAS]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms.
Guanine nucleotide exchange factors (RhoGEFs) and GTPase-activating proteins (RhoGAPs) coordinate the activation state of the Rho family of GTPases for binding to effectors. Here, we exploited proximity-dependent biotinylation to systematically define the Rho family proximity interaction network from 28 baits to produce 9,939 high-confidence proximity interactions in two cell lines. Exploiting the nucleotide states of Rho GTPases, we revealed the ... [more]
Nat. Cell Biol. Dec. 23, 2019; (); [Pubmed: 31871319]
Throughput
- Low Throughput
Additional Notes
- AvgP greater or equal to 0.95 assessed by SAINT express
- BioID
- RHOB-G14V active mutant bait, interaction in Hela cells
Curated By
- BioGRID