BAIT
HTT
AI256365, C430023I11Rik, Hd, Hdh, IT15
huntingtin
GO Process (57)
GO Function (10)
GO Component (21)
Gene Ontology Biological Process
- ER to Golgi vesicle-mediated transport [IMP]
- Golgi organization [ISO]
- L-glutamate import [IMP]
- anatomical structure morphogenesis [IMP]
- anterior/posterior pattern specification [IMP]
- apoptotic process [IMP]
- associative learning [IMP]
- axon cargo transport [IMP]
- brain development [IMP]
- cell aging [IMP]
- central nervous system development [IMP]
- citrulline metabolic process [IMP]
- determination of adult lifespan [IMP]
- dopamine receptor signaling pathway [IMP]
- embryo development [IMP]
- endoplasmic reticulum organization [IMP]
- endosomal transport [IMP]
- establishment of mitotic spindle orientation [ISO]
- gastrulation [IMP]
- grooming behavior [IMP]
- hormone metabolic process [IMP]
- insulin secretion [IMP]
- iron ion homeostasis [IMP]
- lactate biosynthetic process from pyruvate [IMP]
- learning [IMP]
- learning or memory [IMP]
- locomotory behavior [IMP]
- mRNA transport [ISO]
- mitochondrial transport [IMP]
- mitochondrion organization [IMP]
- negative regulation of apoptotic process [IDA]
- negative regulation of cysteine-type endopeptidase activity [ISO]
- negative regulation of extrinsic apoptotic signaling pathway [ISO]
- negative regulation of neuron apoptotic process [IMP]
- negative regulation of neuron death [IMP]
- neural plate formation [IMP]
- neurogenesis [IMP]
- neuron apoptotic process [IMP]
- neuron development [IMP]
- olfactory lobe development [IMP]
- paraxial mesoderm formation [IMP]
- peptide hormone secretion [IMP]
- positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [ISO]
- protein import into nucleus [IMP]
- quinolinate biosynthetic process [IMP]
- regulation of mitochondrial membrane permeability [IMP]
- regulation of mitochondrial membrane potential [IMP]
- regulation of protein phosphatase type 2A activity [ISO]
- regulation of synaptic plasticity [IMP]
- response to calcium ion [IMP]
- retrograde vesicle-mediated transport, Golgi to ER [ISO]
- social behavior [IMP]
- spermatogenesis [IMP]
- striatum development [IMP]
- urea cycle [IMP]
- vesicle transport along microtubule [IDA, ISO]
- visual learning [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- autophagic vacuole [ISO]
- axon [IDA, ISO]
- cell [IMP]
- clathrin-coated vesicle [ISO]
- cytoplasm [IDA, IMP, ISO]
- cytoplasmic membrane-bounded vesicle [IDA]
- cytoplasmic vesicle membrane [ISO]
- cytosol [ISO]
- dendrite [ISO]
- endoplasmic reticulum [ISO]
- inclusion body [IDA]
- intracellular [IMP]
- late endosome [ISO]
- mitochondrion [IMP]
- neuronal cell body [ISO]
- neuronal ribonucleoprotein granule [ISO]
- nucleoplasm [ISO]
- nucleus [IBA, ISO]
- postsynaptic density [ISO]
- protein complex [ISO]
Mus musculus
PREY
RAB8B
5930437D16, D330025I23Rik
RAB8B, member RAS oncogene family
GO Process (15)
GO Function (6)
GO Component (12)
Gene Ontology Biological Process
- GTP catabolic process [IBA]
- Golgi vesicle fusion to target membrane [IBA]
- Rab protein signal transduction [IBA]
- adherens junction organization [ISO]
- antigen processing and presentation [ISO]
- cellular response to insulin stimulus [IBA]
- intracellular protein transport [IBA]
- positive regulation of cell projection organization [ISO]
- positive regulation of corticotropin secretion [ISO]
- protein import into peroxisome membrane [ISO]
- protein localization to plasma membrane [IBA]
- protein secretion [IBA]
- regulation of exocytosis [IBA]
- synaptic vesicle exocytosis [IBA]
- vesicle docking involved in exocytosis [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cell tip [ISO]
- cytoplasmic vesicle [ISO]
- endosome [IBA]
- extracellular vesicular exosome [ISO]
- mitochondrion [IDA]
- perinuclear region of cytoplasm [ISO]
- peroxisomal membrane [ISO]
- phagocytic vesicle [ISO]
- plasma membrane [IBA, ISO]
- secretory granule membrane [IBA]
- synaptic vesicle [IBA]
- trans-Golgi network transport vesicle [IBA]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Network organization of the huntingtin proteomic interactome in mammalian brain.
We used affinity-purification mass spectrometry to identify 747 candidate proteins that are complexed with Huntingtin (Htt) in distinct brain regions and ages in Huntington's disease (HD) and wild-type mouse brains. To gain a systems-level view of the Htt interactome, we applied Weighted Correlation Network Analysis to the entire proteomic data set to unveil a verifiable rank of Htt-correlated proteins and ... [more]
Neuron Jul. 12, 2012; 75(1);41-57 [Pubmed: 22794259]
Throughput
- High Throughput
Curated By
- BioGRID