BAIT
RHOG
ARHG
ras homolog family member G
GO Process (14)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
- GTP catabolic process [IDA, TAS]
- Rac protein signal transduction [IDA]
- Rho protein signal transduction [IDA]
- actin cytoskeleton organization [IDA]
- activation of Rac GTPase activity [IMP]
- axon guidance [TAS]
- blood coagulation [TAS]
- cell chemotaxis [IMP]
- platelet activation [TAS]
- positive regulation of cell proliferation [TAS]
- positive regulation of establishment of protein localization to plasma membrane [IMP]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of small GTPase mediated signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
RPL29
HIP, HUMRPL29, L29, RPL29P10, RPL29_3_370
ribosomal protein L29
GO Process (14)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- SRP-dependent cotranslational protein targeting to membrane [TAS]
- cellular protein metabolic process [TAS]
- embryo implantation [TAS]
- gene expression [TAS]
- mRNA metabolic process [TAS]
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [TAS]
- translation [NAS, TAS]
- translational elongation [TAS]
- translational initiation [TAS]
- translational termination [TAS]
- viral life cycle [TAS]
- viral process [TAS]
- viral transcription [TAS]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms.
Guanine nucleotide exchange factors (RhoGEFs) and GTPase-activating proteins (RhoGAPs) coordinate the activation state of the Rho family of GTPases for binding to effectors. Here, we exploited proximity-dependent biotinylation to systematically define the Rho family proximity interaction network from 28 baits to produce 9,939 high-confidence proximity interactions in two cell lines. Exploiting the nucleotide states of Rho GTPases, we revealed the ... [more]
Nat. Cell Biol. Dec. 23, 2019; (); [Pubmed: 31871319]
Throughput
- High Throughput
Additional Notes
- AvgP greater or equal to 0.95 assessed by SAINT express
- BioID
- RHOG-G15A nucleotide free mutant bait, interaction in Hela cells
Curated By
- BioGRID