BAIT
KCTD5
potassium channel tetramerization domain containing 5
GO Process (0)
GO Function (2)
GO Component (1)
Gene Ontology Molecular Function
Homo sapiens
PREY
GNB2
guanine nucleotide binding protein (G protein), beta polypeptide 2
GO Process (6)
GO Function (4)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Human Multisubunit E3 Ubiquitin Ligase Required for Heterotrimeric G-Protein ?-Subunit Ubiquitination and Downstream Signaling.
G-protein-coupled receptors (GPCRs) initiate intracellular signaling events through heterotrimeric G-protein ?-subunits (G?) and the ??-subunit dimer (G??). In this study, we utilized mass spectrometry to identify novel regulators of G?? signaling in human cells. This prompted our characterization of KCTD2 and KCTD5, two related potassium channel tetramerization domain (KCTD) proteins that specifically recognize G??. We demonstrated that these KCTD proteins ... [more]
J Proteome Res Dec. 03, 2020; 20(9);4318-4330 [Pubmed: 34342229]
Throughput
- High Throughput
Curated By
- BioGRID