BAIT
RAD27
ERC11, FEN1, RTH1, multifunctional nuclease RAD27, L000002742, L000000565, YKL113C
5' to 3' exonuclease, 5' flap endonuclease; required for Okazaki fragment processing and maturation, for long-patch base-excision repair and large loop repair (LLR), ribonucleotide excision repair; member of the S. pombe RAD2/FEN1 family; relocalizes to the cytosol in response to hypoxia
GO Process (6)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
- DNA replication, removal of RNA primer [IDA]
- base-excision repair, base-free sugar-phosphate removal [IGI, IMP]
- double-strand break repair via nonhomologous end joining [IDA]
- gene conversion at mating-type locus, DNA repair synthesis [IMP]
- maintenance of DNA trinucleotide repeats [IGI, IMP]
- replicative cell aging [IMP]
Gene Ontology Molecular Function
Saccharomyces cerevisiae (S288c)
PREY
LCD1
DDC2, PIE1, YDR499W
Essential protein required for the DNA integrity checkpoint pathways; interacts physically with Mec1p; putative homolog of S. pombe Rad26 and human ATRIP; forms nuclear foci upon DNA replication stress
GO Process (3)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
Dosage Growth Defect
A genetic interaction is inferred when over expression or increased dosage of one gene causes a growth defect in a strain that is mutated or deleted for another gene.
Publication
VID22 counteracts G-quadruplex-induced genome instability.
Genome instability is a condition characterized by the accumulation of genetic alterations and is a hallmark of cancer cells. To uncover new genes and cellular pathways affecting endogenous DNA damage and genome integrity, we exploited a Synthetic Genetic Array (SGA)-based screen in yeast. Among the positive genes, we identified VID22, reported to be involved in DNA double-strand break repair. vid22? ... [more]
Nucleic Acids Res Dec. 16, 2020; 49(22);12785-12804 [Pubmed: 34871443]
Throughput
- High Throughput
Ontology Terms
- phenotype: vegetative growth (APO:0000106)
Additional Notes
- Table 1
- synthetic dosage lethality screen with DDC2 overexpression
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RAD27 LCD1 | Dosage Lethality Dosage Lethality A genetic interaction is inferred when over expression or increased dosage of one gene causes lethality in a strain that is mutated or deleted for another gene. | High | - | BioGRID | 166693 |
Curated By
- BioGRID