CDK6
Gene Ontology Biological Process
- Notch signaling pathway [IDA, IGI]
- T cell differentiation in thymus [IMP]
- cell dedifferentiation [ISO]
- gliogenesis [ISO]
- hematopoietic progenitor cell differentiation [IMP]
- hematopoietic stem cell differentiation [IMP]
- hemopoiesis [IMP]
- negative regulation of cell cycle [ISO]
- negative regulation of cellular senescence [ISO]
- negative regulation of epithelial cell proliferation [ISO]
- negative regulation of myeloid cell differentiation [ISO]
- negative regulation of osteoblast differentiation [ISO]
- phosphorylation [IDA]
- positive regulation of cell-matrix adhesion [ISO]
- positive regulation of fibroblast proliferation [ISO]
- positive regulation of gene expression [IDA]
- protein phosphorylation [ISO]
- regulation of erythrocyte differentiation [ISO]
- regulation of gene expression [ISO]
- type B pancreatic cell development [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CDKN2D
Gene Ontology Biological Process
- DNA synthesis involved in DNA repair [ISO]
- G1/S transition of mitotic cell cycle [ISO]
- autophagic cell death [ISO]
- cell cycle arrest [ISO]
- negative regulation of cell growth [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [ISO]
- negative regulation of phosphorylation [ISO]
- negative regulation of protein serine/threonine kinase activity [ISO]
- regulation of cyclin-dependent protein serine/threonine kinase activity [ISO]
- response to UV [ISO]
- response to retinoic acid [ISO]
- response to vitamin D [ISO]
- sensory perception of sound [IMP]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4.
The cell cycle in mammalian cells is regulated by a series of cyclins and cyclin-dependent kinases (CDKs). The G1/S checkpoint is mainly dictated by the kinase activities of the cyclin D-CDK4 and/or cyclin D-CDK6 complex and the cyclin E-CDK2 complex. These G1 kinases can in turn be regulated by cell cycle inhibitors, which may cause the cells to arrest at ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CDKN2D CDK6 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID