BAIT
YTHDC1
YT521, YT521-B
YTH domain containing 1
GO Process (1)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
PRICKLE1
EPM1B, RILP
prickle homolog 1 (Drosophila)
GO Process (7)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
- negative regulation of canonical Wnt signaling pathway [IDA]
- negative regulation of cardiac muscle cell myoblast differentiation [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- neural tube closure [IMP]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IDA]
- positive regulation of protein ubiquitination [IDA]
- protein import into nucleus [IDA, IMP]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation.
N6-Methyladenosine (m6A) on mRNAs mediates different biological processes and its dysregulation contributes to tumorigenesis. How m6A dictates its diverse molecular and cellular effects in leukemias remains unknown. We found that YTHDC1 is the essential m6A reader in myeloid leukemia from a genome-wide CRISPR screen and that m6A is required for YTHDC1 to undergo liquid-liquid phase separation and form nuclear YTHDC1-m6A ... [more]
Cancer Cell Dec. 12, 2020; 39(7);958-972.e8 [Pubmed: 34048709]
Throughput
- High Throughput
Additional Notes
- Hyper-TRIBE
Curated By
- BioGRID