BAIT
GRAMD4
DIP, dA59H18.1, dJ439F8.1, RP6-59H18.4
GRAM domain containing 4
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
ACIN1
ACINUS, ACN, fSAP152
apoptotic chromatin condensation inducer 1
GO Process (8)
GO Function (5)
GO Component (8)
Gene Ontology Biological Process
- ATP catabolic process [NAS]
- apoptotic chromosome condensation [IDA]
- apoptotic process [TAS]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- erythrocyte differentiation [IEP]
- negative regulation of mRNA splicing, via spliceosome [IDA]
- positive regulation of apoptotic process [IDA]
- positive regulation of monocyte differentiation [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
GRAMD4 inhibits tumour metastasis by recruiting the E3 ligase ITCH to target TAK1 for degradation in hepatocellular carcinoma.
Aberrant TAK1 (transforming growth factor ?-activated kinase 1) activity is known to be involved in a variety of malignancies, but the regulatory mechanisms of TAK1 remain poorly understood. GRAMD4 (glucosyltransferase Rab-like GTPase activator and myotubularin domain containing 4) is a newly discovered p53-independent proapoptotic protein with an unclear role in HCC (hepatocellular carcinoma).In this research, we found that GRAMD4 expression ... [more]
Clin Transl Med Dec. 01, 2020; 11(11);e635 [Pubmed: 34841685]
Throughput
- Low Throughput
Curated By
- BioGRID