BAIT
SOX2
ANOP3, MCOPS3
SRY (sex determining region Y)-box 2
GO Process (23)
GO Function (6)
GO Component (5)
Gene Ontology Biological Process
- cell cycle arrest [IDA]
- chromatin organization [NAS]
- endodermal cell fate specification [IDA]
- eye development [IEP]
- forebrain development [IEP]
- glial cell fate commitment [NAS]
- inner ear development [IEP]
- negative regulation of canonical Wnt signaling pathway [IDA]
- negative regulation of epithelial cell proliferation [IDA]
- negative regulation of neuron differentiation [ISS]
- negative regulation of transcription from RNA polymerase II promoter [ISS]
- neuronal stem cell maintenance [ISS]
- osteoblast differentiation [IDA]
- pituitary gland development [IEP]
- positive regulation of MAPK cascade [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- regulation of gene expression [IMP]
- regulation of transcription, DNA-templated [IDA, NAS]
- response to growth factor [IDA]
- response to wounding [IEP]
- somatic stem cell maintenance [IDA, IMP]
Gene Ontology Molecular Function
Homo sapiens
PREY
CLU
APO-J, APOJ, CLI, CLU1, CLU2, KUB1, NA1/NA2, SGP-2, SGP2, SP-40, TRPM-2, TRPM2, AAG4
clusterin
GO Process (35)
GO Function (4)
GO Component (12)
Gene Ontology Biological Process
- blood coagulation [TAS]
- cell morphogenesis [IDA]
- central nervous system myelin maintenance [IMP]
- chaperone-mediated protein complex assembly [IDA]
- chaperone-mediated protein folding [IDA]
- complement activation [TAS]
- intrinsic apoptotic signaling pathway [IDA]
- lipid metabolic process [NAS]
- microglial cell activation [IDA]
- microglial cell proliferation [IDA]
- negative regulation of beta-amyloid formation [IDA]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [IMP]
- negative regulation of protein homooligomerization [IMP]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of NF-kappaB transcription factor activity [IMP]
- positive regulation of apoptotic process [IMP]
- positive regulation of beta-amyloid formation [ISS]
- positive regulation of intrinsic apoptotic signaling pathway [IMP]
- positive regulation of neurofibrillary tangle assembly [IMP]
- positive regulation of neuron death [IDA, IMP]
- positive regulation of nitric oxide biosynthetic process [IDA]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IMP]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IMP]
- positive regulation of tau-protein kinase activity [IMP]
- positive regulation of tumor necrosis factor production [IDA]
- protein import [IDA]
- protein stabilization [IDA]
- regulation of beta-amyloid clearance [IDA]
- regulation of neuron death [IDA, IMP]
- regulation of neuronal signal transduction [IMP]
- release of cytochrome c from mitochondria [IC]
- response to misfolded protein [IDA]
- response to virus [IEP]
- reverse cholesterol transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- apical dendrite [IDA]
- blood microparticle [IDA]
- cytoplasm [IDA]
- extracellular matrix [IDA]
- extracellular region [TAS]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- mitochondrion [IDA]
- neurofibrillary tangle [IDA]
- perinuclear region of cytoplasm [IDA]
- platelet alpha granule lumen [TAS]
- spherical high-density lipoprotein particle [IDA]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma.
The pluripotency transcription factor SOX2 is essential for the maintenance of glioblastoma stem cells (GSC), which are thought to underlie tumor growth, treatment resistance, and recurrence. To understand how SOX2 is regulated in GSCs, we utilized a proteomic approach and identified the E3 ubiquitin ligase TRIM26 as a direct SOX2-interacting protein. Unexpectedly, we found TRIM26 depletion decreased SOX2 protein levels ... [more]
Nat Commun Dec. 03, 2020; 12(1);6321 [Pubmed: 34732716]
Throughput
- Low Throughput
Curated By
- BioGRID