CAPZB
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
LRRC16A
Gene Ontology Biological Process
- actin filament organization [NAS]
- barbed-end actin filament uncapping [ISS]
- blood coagulation [TAS]
- cell migration [IMP]
- lamellipodium assembly [IMP]
- negative regulation of barbed-end actin filament capping [ISS]
- positive regulation of actin filament polymerization [ISS]
- positive regulation of cell migration [IMP]
- positive regulation of lamellipodium organization [IDA]
- positive regulation of stress fiber assembly [IMP]
- positive regulation of substrate adhesion-dependent cell spreading [IMP]
- ruffle organization [IMP]
- urate metabolic process [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Elucidating the wiring diagram of the human cell is a central goal of the postgenomic era. We combined genome engineering, confocal live-cell imaging, mass spectrometry, and data science to systematically map the localization and interactions of human proteins. Our approach provides a data-driven description of the molecular and spatial networks that organize the proteome. Unsupervised clustering of these networks delineates ... [more]
Throughput
- High Throughput
Additional Notes
- Bait generated from library of CRISPR-edited human embryonic kidney (HEK) 293T cell lines harboring fluorescent tags on individual proteins
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CAPZB LRRC16A | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 3063207 | |
| LRRC16A CAPZB | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | 0.6237 | BioGRID | 1259604 |
Curated By
- BioGRID