BAIT
CSNK2A2
CK2A2, CSNK2A1
casein kinase 2, alpha prime polypeptide
GO Process (3)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
LTF
GIG12, HEL110, HLF2, LF
lactotransferrin
GO Process (25)
GO Function (5)
GO Component (7)
Gene Ontology Biological Process
- antibacterial humoral response [IDA]
- antifungal humoral response [IDA]
- bone morphogenesis [IDA]
- humoral immune response [TAS]
- innate immune response in mucosa [IDA]
- interaction with host [TAS]
- iron assimilation by chelation and transport [TAS]
- negative regulation of apoptotic process [ISS]
- negative regulation of lipopolysaccharide-mediated signaling pathway [IDA]
- negative regulation of osteoclast development [ISS]
- negative regulation of single-species biofilm formation in or on host organism [IDA]
- negative regulation of tumor necrosis factor (ligand) superfamily member 11 production [ISS]
- phagosome maturation [TAS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of bone mineralization involved in bone maturation [ISS]
- positive regulation of chondrocyte proliferation [IDA]
- positive regulation of osteoblast differentiation [IDA]
- positive regulation of osteoblast proliferation [IDA]
- positive regulation of protein serine/threonine kinase activity [IDA]
- positive regulation of toll-like receptor 4 signaling pathway [IMP]
- regulation of cytokine production [IDA]
- regulation of tumor necrosis factor production [IDA]
- response to host immune response [TAS]
- retina homeostasis [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Elucidating the wiring diagram of the human cell is a central goal of the postgenomic era. We combined genome engineering, confocal live-cell imaging, mass spectrometry, and data science to systematically map the localization and interactions of human proteins. Our approach provides a data-driven description of the molecular and spatial networks that organize the proteome. Unsupervised clustering of these networks delineates ... [more]
Science Dec. 11, 2021; 375(6585);eabi6983 [Pubmed: 35271311]
Throughput
- High Throughput
Additional Notes
- Bait generated from library of CRISPR-edited human embryonic kidney (HEK) 293T cell lines harboring fluorescent tags on individual proteins
Curated By
- BioGRID