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BAIT

DNAJC11

dJ126A5.1, RP1-126A5.3

DnaJ (Hsp40) homolog, subfamily C, member 11

GO Process (0)

GO Function (1)

GO Component (1)

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

extracellular vesicular exosome [IDA]

CRISPR Database VEGA OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

VCP

ALS14, HEL-220, HEL-S-70, IBMPFD, IBMPFD1, TERA, p97

valosin containing protein

Autophagy Project

GO Process (18)

GO Function (8)

GO Component (13)

Gene Ontology Biological Process

DNA repair [NAS]

ER-associated ubiquitin-dependent protein catabolic process [IDA, IMP, TAS]

activation of cysteine-type endopeptidase activity involved in apoptotic process [ISS]

cellular response to DNA damage stimulus [IDA]

double-strand break repair [IDA]

endoplasmic reticulum unfolded protein response [TAS]

establishment of protein localization [TAS]

positive regulation of Lys63-specific deubiquitinase activity [IDA]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IDA]

positive regulation of protein K63-linked deubiquitination [IDA]

positive regulation of protein catabolic process [IDA]

positive regulation of protein complex assembly [IDA]

proteasome-mediated ubiquitin-dependent protein catabolic process [NAS]

protein N-linked glycosylation via asparagine [IMP]

protein ubiquitination [IDA, NAS]

regulation of apoptotic process [TAS]

retrograde protein transport, ER to cytosol [IDA]

translesion synthesis [IMP]

Gene Ontology Molecular Function

ATPase activity [TAS]
deubiquitinase activator activity [IDA]
poly(A) RNA binding [IDA]
polyubiquitin binding [IDA]
protein binding [IPI]
protein domain specific binding [IPI]
protein phosphatase binding [IPI]
ubiquitin-specific protease binding [IPI]

Gene Ontology Cellular Component

Hrd1p ubiquitin ligase complex [IDA]

cytoplasm [IDA]

endoplasmic reticulum [IDA]

endoplasmic reticulum membrane [IDA]

extracellular vesicular exosome [IDA]

intracellular membrane-bounded organelle [ISS]

lipid particle [IDA]

nucleoplasm [IDA]

nucleus [IDA, TAS]

perinuclear region of cytoplasm [IDA]

proteasome complex [IDA]

site of double-strand break [IDA]

CRISPR Database HGNC Alliance of Genome Resources OMIM VEGA Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

OpenCell: Endogenous tagging for the cartography of human cellular organization.

Cho NH, Cheveralls KC, Brunner AD, Kim K, Michaelis AC, Raghavan P, Kobayashi H, Savy L, Li JY, Canaj H, Kim JYS, Stewart EM, Gnann C, McCarthy F, Cabrera JP, Brunetti RM, Chhun BB, Dingle G, Hein MY, Huang B, Mehta SB, Weissman JS, Gomez-Sjoeberg R, Itzhak DN, Royer LA, Mann M, Leonetti MD

Elucidating the wiring diagram of the human cell is a central goal of the postgenomic era. We combined genome engineering, confocal live-cell imaging, mass spectrometry, and data science to systematically map the localization and interactions of human proteins. Our approach provides a data-driven description of the molecular and spatial networks that organize the proteome. Unsupervised clustering of these networks delineates ... [more]

Science Dec. 11, 2021; 375(6585);eabi6983 [Pubmed: 35271311]

Throughput

High Throughput

Additional Notes

Bait generated from library of CRISPR-edited human embryonic kidney (HEK) 293T cell lines harboring fluorescent tags on individual proteins

Curated By

BioGRID