RPN4
Gene Ontology Biological Process
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription from RNA polymerase II promoter in response to stress [IMP]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IGI, IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP]
- positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance [IMP]
- positive regulation of transcription from RNA polymerase II promoter in response to stress [IEP, IMP]
- regulation of DNA repair [IMP]
Gene Ontology Molecular Function
RPT4
Gene Ontology Biological Process
- ER-associated ubiquitin-dependent protein catabolic process [IMP]
- nucleotide-excision repair [IGI]
- positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [IMP]
- positive regulation of transcription elongation from RNA polymerase II promoter [IMP]
- proteasome regulatory particle assembly [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Growth Defect
A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.
Publication
Hexameric assembly of the proteasomal ATPases is templated through their C termini.
Substrates of the proteasome are recognized and unfolded by the regulatory particle, and then translocated into the core particle (CP) to be degraded. A hetero-hexameric ATPase ring, containing subunits Rpt1-6, is situated within the base subassembly of the regulatory particle. The ATPase ring sits atop the CP, with the Rpt carboxy termini inserted into pockets in the CP. Here we ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: vegetative growth (APO:0000106)
- phenotype: resistance to chemicals (APO:0000087)
- phenotype: heat sensitivity (APO:0000147)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RPT4 RPN4 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1847 | BioGRID | 417093 | |
| RPN4 RPT4 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.5395 | BioGRID | 2031890 | |
| RPT4 RPN4 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.4413 | BioGRID | 2018354 |
Curated By
- BioGRID