NHP6A
Gene Ontology Biological Process
- DNA replication-independent nucleosome organization [IDA]
- RNA polymerase II transcriptional preinitiation complex assembly [IDA]
- RNA polymerase III transcriptional preinitiation complex assembly [IDA, IGI]
- chromatin remodeling [IGI]
- maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase III promoter [IDA]
- mismatch repair [IC]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
IES5
Gene Ontology Biological Process
Gene Ontology Cellular Component
Synthetic Growth Defect
A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.
Publication
Linking functionally related genes by sensitive and quantitative characterization of genetic interaction profiles.
Describing at a genomic scale how mutations in different genes influence one another is essential to the understanding of how genotype correlates with phenotype and remains a major challenge in biology. Previous studies pointed out the need for accurate measurements of not only synthetic but also buffering interactions in the characterization of genetic networks and functional modules. We developed a ... [more]
Throughput
- High Throughput
Ontology Terms
- phenotype: vegetative growth (APO:0000106)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| IES5 NHP6A | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -3.5716 | BioGRID | 508011 |
Curated By
- BioGRID