BAIT
INPP5K
PPS, SKIP
inositol polyphosphate-5-phosphatase K
GO Process (37)
GO Function (8)
GO Component (11)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [ISS]
- actin cytoskeleton organization [NAS]
- cellular response to cAMP [ISS]
- cellular response to epidermal growth factor stimulus [IDA]
- cellular response to hormone stimulus [ISS]
- cellular response to insulin stimulus [IDA]
- cellular response to tumor necrosis factor [IDA]
- dephosphorylation [IDA, IMP]
- glucose homeostasis [ISS]
- inositol phosphate dephosphorylation [IDA]
- negative regulation by host of viral transcription [IDA]
- negative regulation of MAP kinase activity [IDA]
- negative regulation of calcium ion transport [IDA]
- negative regulation of dephosphorylation [ISS]
- negative regulation of glucose transport [IDA]
- negative regulation of glycogen (starch) synthase activity [ISS]
- negative regulation of glycogen biosynthetic process [IDA]
- negative regulation of insulin receptor signaling pathway [IDA]
- negative regulation of peptidyl-serine phosphorylation [IDA]
- negative regulation of peptidyl-threonine phosphorylation [IDA]
- negative regulation of protein kinase B signaling [IDA]
- negative regulation of protein kinase activity [IDA]
- negative regulation of protein phosphorylation [ISS]
- negative regulation of protein targeting to membrane [IDA]
- negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [IDA]
- negative regulation of stress fiber assembly [IDA]
- negative regulation of transcription, DNA-templated [ISS]
- phosphatidylinositol biosynthetic process [TAS]
- phosphatidylinositol dephosphorylation [IDA]
- phospholipid metabolic process [TAS]
- positive regulation of renal water transport [ISS]
- positive regulation of transcription, DNA-templated [ISS]
- positive regulation of urine volume [ISS]
- protein targeting to plasma membrane [ISS]
- regulation of glycogen biosynthetic process [ISS]
- ruffle assembly [IDA]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function- inositol bisphosphate phosphatase activity [IDA]
- inositol trisphosphate phosphatase activity [IDA]
- lipid phosphatase activity [NAS]
- phosphatidylinositol phosphate 5-phosphatase activity [IMP]
- phosphatidylinositol trisphosphate phosphatase activity [IDA]
- phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity [IDA]
- protein binding [IPI]
- vasopressin receptor activity [ISS]
- inositol bisphosphate phosphatase activity [IDA]
- inositol trisphosphate phosphatase activity [IDA]
- lipid phosphatase activity [NAS]
- phosphatidylinositol phosphate 5-phosphatase activity [IMP]
- phosphatidylinositol trisphosphate phosphatase activity [IDA]
- phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity [IDA]
- protein binding [IPI]
- vasopressin receptor activity [ISS]
Gene Ontology Cellular Component
Homo sapiens
PREY
HSPD1
CPN60, GROEL, HLD4, HSP-60, HSP60, HSP65, HuCHA60, SPG13
heat shock 60kDa protein 1 (chaperonin)
GO Process (24)
GO Function (11)
GO Component (16)
Gene Ontology Biological Process
- 'de novo' protein folding [ISS]
- ATP catabolic process [ISS]
- B cell activation [IDA]
- B cell cytokine production [IDA]
- B cell proliferation [IDA]
- MyD88-dependent toll-like receptor signaling pathway [IDA]
- T cell activation [IDA]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- chaperone-mediated protein complex assembly [ISS]
- isotype switching to IgG isotypes [IDA]
- negative regulation of apoptotic process [IMP]
- positive regulation of T cell activation [IDA, ISS]
- positive regulation of T cell mediated immune response to tumor cell [IDA]
- positive regulation of apoptotic process [IMP]
- positive regulation of interferon-alpha production [IDA]
- positive regulation of interferon-gamma production [IDA, ISS]
- positive regulation of interleukin-10 production [IDA]
- positive regulation of interleukin-12 production [IDA]
- positive regulation of interleukin-6 production [IDA]
- positive regulation of macrophage activation [IDA]
- protein maturation [ISS]
- protein refolding [IDA]
- protein stabilization [IMP, ISS]
- response to unfolded protein [IDA]
Gene Ontology Molecular Function- ATPase activity [ISS]
- DNA replication origin binding [ISS]
- chaperone binding [IPI]
- double-stranded RNA binding [IDA]
- lipopolysaccharide binding [IDA]
- p53 binding [IPI]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- single-stranded DNA binding [ISS]
- ubiquitin protein ligase binding [IPI]
- unfolded protein binding [IC, ISS]
- ATPase activity [ISS]
- DNA replication origin binding [ISS]
- chaperone binding [IPI]
- double-stranded RNA binding [IDA]
- lipopolysaccharide binding [IDA]
- p53 binding [IPI]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- single-stranded DNA binding [ISS]
- ubiquitin protein ligase binding [IPI]
- unfolded protein binding [IC, ISS]
Gene Ontology Cellular Component
- cell surface [IDA]
- coated pit [IDA]
- coated vesicle [IDA]
- cyclin-dependent protein kinase activating kinase holoenzyme complex [IDA]
- cytoplasm [IDA]
- cytosol [IDA]
- early endosome [IDA]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- lipopolysaccharide receptor complex [IDA]
- membrane [IDA]
- mitochondrial inner membrane [ISS]
- mitochondrial matrix [TAS]
- mitochondrion [IDA]
- protein complex [IDA]
- secretory granule [ISS]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Elucidating the wiring diagram of the human cell is a central goal of the postgenomic era. We combined genome engineering, confocal live-cell imaging, mass spectrometry, and data science to systematically map the localization and interactions of human proteins. Our approach provides a data-driven description of the molecular and spatial networks that organize the proteome. Unsupervised clustering of these networks delineates ... [more]
Science Dec. 11, 2021; 375(6585);eabi6983 [Pubmed: 35271311]
Throughput
- High Throughput
Additional Notes
- Bait generated from library of CRISPR-edited human embryonic kidney (HEK) 293T cell lines harboring fluorescent tags on individual proteins
Curated By
- BioGRID