BAIT
RAB1A
RAB1, YPT1
RAB1A, member RAS oncogene family
GO Process (19)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- ER to Golgi vesicle-mediated transport [IGI, IMP]
- GTP catabolic process [IDA]
- Golgi organization [IMP]
- Rab protein signal transduction [IBA]
- autophagic vacuole assembly [IMP]
- autophagy [IMP]
- cargo loading into COPII-coated vesicle [IMP]
- cell migration [IMP]
- cilium assembly [IMP]
- defense response to bacterium [IMP]
- endocytosis [IMP]
- growth hormone secretion [IMP]
- interleukin-8 secretion [IMP]
- intracellular protein transport [IBA]
- mitotic cell cycle [TAS]
- positive regulation of glycoprotein metabolic process [IGI]
- vesicle transport along microtubule [IMP]
- vesicle-mediated transport [TAS]
- virion assembly [IGI, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SCFD1
C14orf163, RA410, SLY1, SLY1P, STXBP1L2, FKSG23
sec1 family domain containing 1
GO Process (8)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- cell morphogenesis [ISS]
- negative regulation of autophagic vacuole assembly [IMP]
- phagocytosis [ISS]
- post-Golgi vesicle-mediated transport [ISS]
- regulation of ER to Golgi vesicle-mediated transport [ISS]
- regulation of protein transport [IMP]
- response to toxic substance [IEP]
- retrograde vesicle-mediated transport, Golgi to ER [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Elucidating the wiring diagram of the human cell is a central goal of the postgenomic era. We combined genome engineering, confocal live-cell imaging, mass spectrometry, and data science to systematically map the localization and interactions of human proteins. Our approach provides a data-driven description of the molecular and spatial networks that organize the proteome. Unsupervised clustering of these networks delineates ... [more]
Science Dec. 11, 2021; 375(6585);eabi6983 [Pubmed: 35271311]
Throughput
- High Throughput
Additional Notes
- Bait generated from library of CRISPR-edited human embryonic kidney (HEK) 293T cell lines harboring fluorescent tags on individual proteins
Curated By
- BioGRID