RAB7A
Gene Ontology Biological Process
- GTP catabolic process [IDA, TAS]
- Rab protein signal transduction [IBA]
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- early endosome to late endosome transport [IMP]
- endocytosis [TAS]
- endosome to lysosome transport [IMP]
- epidermal growth factor catabolic process [IMP]
- phagosome acidification [IMP]
- phagosome maturation [TAS]
- phagosome-lysosome fusion [IMP]
- positive regulation of exosomal secretion [IMP]
- protein targeting to lysosome [IMP]
- protein to membrane docking [IDA]
- protein transport [TAS]
- regulation of autophagic vacuole assembly [IMP]
- retrograde transport, endosome to Golgi [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
VAMP7
Gene Ontology Biological Process
- ER to Golgi vesicle-mediated transport [ISS]
- autophagic vacuole fusion [IMP]
- calcium ion-dependent exocytosis [ISS]
- endocytosis [IBA]
- endosome to lysosome transport [IDA]
- eosinophil degranulation [IMP, ISS]
- exocytosis [IBA]
- membrane organization [TAS]
- natural killer cell degranulation [IMP]
- neutrophil degranulation [IMP, ISS]
- phagocytosis, engulfment [ISS]
- positive regulation of histamine secretion by mast cell [IMP]
- post-Golgi vesicle-mediated transport [TAS]
- vesicle fusion [IDA]
- vesicle-mediated transport [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- SNARE complex [IDA, ISS]
- azurophil granule membrane [IDA]
- cytoplasm [IDA]
- endoplasmic reticulum membrane [ISS]
- extracellular vesicular exosome [IDA]
- intracellular membrane-bounded organelle [IDA]
- lamellipodium [IDA]
- late endosome membrane [ISS]
- lysosomal membrane [IDA, ISS, TAS]
- membrane [IDA]
- neuron projection [ISS]
- phagocytic vesicle [ISS]
- plasma membrane [IDA, TAS]
- platelet alpha granule [IDA]
- pseudopodium [IDA]
- secretory granule [IDA]
- secretory granule membrane [IDA]
- trans-Golgi network [IDA]
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Elucidating the wiring diagram of the human cell is a central goal of the postgenomic era. We combined genome engineering, confocal live-cell imaging, mass spectrometry, and data science to systematically map the localization and interactions of human proteins. Our approach provides a data-driven description of the molecular and spatial networks that organize the proteome. Unsupervised clustering of these networks delineates ... [more]
Throughput
- High Throughput
Additional Notes
- Bait generated from library of CRISPR-edited human embryonic kidney (HEK) 293T cell lines harboring fluorescent tags on individual proteins
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
RAB7A VAMP7 | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | High | 0 | BioGRID | 3378925 |
Curated By
- BioGRID