RTN4
Gene Ontology Biological Process
- apoptotic process [NAS]
- axonal fasciculation [IBA, ISS]
- cerebral cortex radial glia guided migration [ISS]
- endoplasmic reticulum tubular network organization [IMP]
- negative regulation of axon extension [IDA]
- negative regulation of axonogenesis [TAS]
- negative regulation of cell growth [IMP]
- neurotrophin TRK receptor signaling pathway [TAS]
- regulation of apoptotic process [NAS]
- regulation of axonogenesis [TAS]
- regulation of branching morphogenesis of a nerve [ISS]
- regulation of cell migration [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
BCAP31
Gene Ontology Biological Process
- antigen processing and presentation of peptide antigen via MHC class I [TAS]
- apoptotic process [TAS]
- calcium-mediated signaling using intracellular calcium source [IMP]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- negative regulation of endoplasmic reticulum calcium ion concentration [IMP]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- positive regulation of cytosolic calcium ion concentration [IMP]
- positive regulation of intrinsic apoptotic signaling pathway [IMP]
- positive regulation of mitochondrial calcium ion concentration [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Elucidating the wiring diagram of the human cell is a central goal of the postgenomic era. We combined genome engineering, confocal live-cell imaging, mass spectrometry, and data science to systematically map the localization and interactions of human proteins. Our approach provides a data-driven description of the molecular and spatial networks that organize the proteome. Unsupervised clustering of these networks delineates ... [more]
Throughput
- High Throughput
Additional Notes
- Bait generated from library of CRISPR-edited human embryonic kidney (HEK) 293T cell lines harboring fluorescent tags on individual proteins
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
BCAP31 RTN4 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | - | BioGRID | 3445157 | |
BCAP31 RTN4 | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | High | 7.33 | BioGRID | 2980928 |
Curated By
- BioGRID