BAIT
SLC7A6
LAT-2, LAT3, y+LAT-2
solute carrier family 7 (amino acid transporter light chain, y+L system), member 6
GO Process (8)
GO Function (0)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Homo sapiens
PREY
LZTS1
F37, FEZ1
leucine zipper, putative tumor suppressor 1
GO Process (9)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- gene expression [TAS]
- innate immune response [TAS]
- negative regulation of macroautophagy [IMP]
- positive regulation of type I interferon production [TAS]
- regulation of transcription, DNA-templated [TAS]
- termination of RNA polymerase III transcription [TAS]
- transcription elongation from RNA polymerase III promoter [TAS]
- transcription from RNA polymerase III promoter [TAS]
- transcription, DNA-templated [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cytosol [TAS]
- nucleoplasm [TAS]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Elucidating the wiring diagram of the human cell is a central goal of the postgenomic era. We combined genome engineering, confocal live-cell imaging, mass spectrometry, and data science to systematically map the localization and interactions of human proteins. Our approach provides a data-driven description of the molecular and spatial networks that organize the proteome. Unsupervised clustering of these networks delineates ... [more]
Science Dec. 11, 2021; 375(6585);eabi6983 [Pubmed: 35271311]
Throughput
- High Throughput
Additional Notes
- Bait generated from library of CRISPR-edited human embryonic kidney (HEK) 293T cell lines harboring fluorescent tags on individual proteins
Curated By
- BioGRID