TOP2A
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- DNA ligation [IDA]
- DNA topological change [IDA]
- DNA unwinding involved in DNA replication [IBA]
- apoptotic chromosome condensation [IDA]
- cellular response to DNA damage stimulus [IDA]
- chromosome segregation [IMP]
- mitotic DNA integrity checkpoint [IBA]
- mitotic cell cycle [TAS]
- mitotic recombination [IBA]
- positive regulation of apoptotic process [IDA]
- positive regulation of single stranded viral RNA replication via double stranded DNA intermediate [IMP]
- positive regulation of viral genome replication [IMP]
- resolution of meiotic recombination intermediates [IBA]
- sister chromatid segregation [IBA]
Gene Ontology Molecular Function- DNA binding [IDA]
- DNA binding, bending [IDA]
- DNA topoisomerase type II (ATP-hydrolyzing) activity [IDA]
- DNA-dependent ATPase activity [IDA]
- chromatin binding [IDA]
- drug binding [IDA]
- enzyme binding [IPI]
- histone deacetylase binding [IPI]
- magnesium ion binding [IDA]
- poly(A) RNA binding [IDA]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [IPI]
- protein kinase C binding [IPI]
- ubiquitin binding [IMP]
- DNA binding [IDA]
- DNA binding, bending [IDA]
- DNA topoisomerase type II (ATP-hydrolyzing) activity [IDA]
- DNA-dependent ATPase activity [IDA]
- chromatin binding [IDA]
- drug binding [IDA]
- enzyme binding [IPI]
- histone deacetylase binding [IPI]
- magnesium ion binding [IDA]
- poly(A) RNA binding [IDA]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [IPI]
- protein kinase C binding [IPI]
- ubiquitin binding [IMP]
Gene Ontology Cellular Component
RPL15
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- SRP-dependent cotranslational protein targeting to membrane [TAS]
- cellular protein metabolic process [TAS]
- gene expression [TAS]
- mRNA metabolic process [TAS]
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [TAS]
- translation [NAS, TAS]
- translational elongation [TAS]
- translational initiation [TAS]
- translational termination [TAS]
- viral life cycle [TAS]
- viral process [TAS]
- viral transcription [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Elucidating the wiring diagram of the human cell is a central goal of the postgenomic era. We combined genome engineering, confocal live-cell imaging, mass spectrometry, and data science to systematically map the localization and interactions of human proteins. Our approach provides a data-driven description of the molecular and spatial networks that organize the proteome. Unsupervised clustering of these networks delineates ... [more]
Throughput
- High Throughput
Additional Notes
- Bait generated from library of CRISPR-edited human embryonic kidney (HEK) 293T cell lines harboring fluorescent tags on individual proteins
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RPL15 TOP2A | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9795 | BioGRID | 3079315 |
Curated By
- BioGRID