BAIT

C17ORF53

chromosome 17 open reading frame 53
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY

AIP

ARA9, FKBP16, FKBP37, SMTPHN, XAP-2, XAP2
aryl hydrocarbon receptor interacting protein
Homo sapiens

Proximity Label-MS

An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.

Publication

MCM8IP activates the MCM8-9 helicase to promote DNA synthesis and homologous recombination upon DNA damage.

Huang JW, Acharya A, Taglialatela A, Nambiar TS, Cuella-Martin R, Leuzzi G, Hayward SB, Joseph SA, Brunette GJ, Anand R, Soni RK, Clark NL, Bernstein KA, Cejka P, Ciccia A

Homologous recombination (HR) mediates the error-free repair of DNA double-strand breaks to maintain genomic stability. Here we characterize C17orf53/MCM8IP, an OB-fold containing protein that binds ssDNA, as a DNA repair factor involved in HR. MCM8IP-deficient cells exhibit HR defects, especially in long-tract gene conversion, occurring downstream of RAD51 loading, consistent with a role for MCM8IP in HR-dependent DNA synthesis. Moreover, ... [more]

Nat Commun Dec. 11, 2019; 11(1);2948 [Pubmed: 32528060]

Throughput

  • Low Throughput

Curated By

  • BioGRID