BAIT

RAB7A

PRO2706, RAB7
RAB7A, member RAS oncogene family
Autophagy Project
Homo sapiens
PREY

ESYT1

FAM62A, MBC2
extended synaptotagmin-like protein 1
GO Process (0)
GO Function (2)
GO Component (3)

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Proximity Label-MS

An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.

Publication

C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.

Yan BR, Li T, Coyaud E, Laurent EMN, St-Germain J, Zhou Y, Kim PK, Raught B, Brumell JH

Depolarized mitochondria can be degraded via mitophagy, a selective form of autophagy. The RAB GTPase RAB7A was recently shown to play a key role in this process. RAB7A regulates late endocytic trafficking under normal growth conditions but is translocated to the mitochondrial surface following depolarization. However, how RAB7A activity is regulated during mitophagy is not understood. Here, using a proximity-dependent ... [more]

Autophagy Aug. 25, 2021; ();1-12 [Pubmed: 34432599]

Quantitative Score

  • 0.0 [Confidence Score]

Throughput

  • High Throughput

Additional Notes

  • +CCCP WT score 0
  • -CCCP WT score 0
  • Proximity Label-MS was carried out to identify high confidence protein-protein interactors with FDR<1% (FDR reported)

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
RAB7A ESYT1
Affinity Capture-MS
Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Low-BioGRID
-

Curated By

  • BioGRID