BAIT
RAB7A
PRO2706, RAB7
RAB7A, member RAS oncogene family
GO Process (16)
GO Function (4)
GO Component (8)
Gene Ontology Biological Process
- GTP catabolic process [IDA, TAS]
- Rab protein signal transduction [IBA]
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- early endosome to late endosome transport [IMP]
- endocytosis [TAS]
- endosome to lysosome transport [IMP]
- epidermal growth factor catabolic process [IMP]
- phagosome acidification [IMP]
- phagosome maturation [TAS]
- phagosome-lysosome fusion [IMP]
- positive regulation of exosomal secretion [IMP]
- protein targeting to lysosome [IMP]
- protein to membrane docking [IDA]
- protein transport [TAS]
- regulation of autophagic vacuole assembly [IMP]
- retrograde transport, endosome to Golgi [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PTPN1
PTP1B
protein tyrosine phosphatase, non-receptor type 1
GO Process (19)
GO Function (8)
GO Component (5)
Gene Ontology Biological Process
- JAK-STAT cascade involved in growth hormone signaling pathway [TAS]
- actin cytoskeleton reorganization [IMP]
- blood coagulation [TAS]
- cytokine-mediated signaling pathway [TAS]
- endoplasmic reticulum unfolded protein response [IDA]
- interferon-gamma-mediated signaling pathway [TAS]
- negative regulation of ERK1 and ERK2 cascade [ISS]
- negative regulation of insulin receptor signaling pathway [NAS]
- negative regulation of vascular endothelial growth factor receptor signaling pathway [ISS]
- peptidyl-tyrosine dephosphorylation [IDA, IMP]
- peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity [ISS]
- platelet activation [TAS]
- platelet-derived growth factor receptor-beta signaling pathway [IMP]
- regulation of endocytosis [IDA]
- regulation of hepatocyte growth factor receptor signaling pathway [IMP]
- regulation of interferon-gamma-mediated signaling pathway [TAS]
- regulation of signal transduction [IMP]
- regulation of type I interferon-mediated signaling pathway [TAS]
- type I interferon signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.
Depolarized mitochondria can be degraded via mitophagy, a selective form of autophagy. The RAB GTPase RAB7A was recently shown to play a key role in this process. RAB7A regulates late endocytic trafficking under normal growth conditions but is translocated to the mitochondrial surface following depolarization. However, how RAB7A activity is regulated during mitophagy is not understood. Here, using a proximity-dependent ... [more]
Autophagy Aug. 25, 2021; ();1-12 [Pubmed: 34432599]
Quantitative Score
- 0.02 [Confidence Score]
Throughput
- High Throughput
Additional Notes
- +CCCP WT score 0
- -CCCP WT score 0.02
- Proximity Label-MS was carried out to identify high confidence protein-protein interactors with FDR<1% (FDR reported)
Curated By
- BioGRID