BAIT
SNX27
MRT1, MY014, RP11-98D18.12-005
sorting nexin family member 27
GO Process (4)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PDGFA
PDGF-A, PDGF1
platelet-derived growth factor alpha polypeptide
GO Process (44)
GO Function (7)
GO Component (7)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- actin cytoskeleton organization [ISS]
- angiogenesis [ISS]
- blood coagulation [TAS]
- cell activation [TAS]
- cell projection assembly [ISS]
- cell-cell signaling [TAS]
- embryonic lung development [ISS]
- epidermal growth factor receptor signaling pathway [TAS]
- extracellular matrix organization [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- hair follicle development [ISS]
- innate immune response [TAS]
- lung alveolus development [ISS]
- negative chemotaxis [IDA]
- negative regulation of phosphatidylinositol biosynthetic process [IDA]
- negative regulation of platelet activation [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- organ morphogenesis [ISS]
- phosphatidylinositol-mediated signaling [TAS]
- platelet activation [TAS]
- platelet degranulation [TAS]
- platelet-derived growth factor receptor signaling pathway [IDA]
- positive regulation of DNA replication [IDA]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of MAP kinase activity [IDA]
- positive regulation of MAPK cascade [IMP]
- positive regulation of cell migration [IDA]
- positive regulation of cell proliferation [IDA]
- positive regulation of fibroblast proliferation [IDA]
- positive regulation of mesenchymal cell proliferation [ISS]
- positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway [IDA]
- positive regulation of phosphatidylinositol 3-kinase signaling [IDA]
- positive regulation of protein autophosphorylation [IDA]
- positive regulation of protein kinase B signaling [IDA]
- regulation of DNA biosynthetic process [IDA]
- regulation of actin cytoskeleton organization [TAS]
- regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling [ISS]
- regulation of glomerular mesangial cell proliferation [IDA]
- regulation of peptidyl-tyrosine phosphorylation [ISS]
- regulation of smooth muscle cell migration [IDA]
- response to wounding [IDA]
- skin development [ISS]
- wound healing [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-?B signalling activation.
Linear ubiquitination is a novel type of ubiquitination that plays important physiological roles in signalling pathways such as tumour necrosis factor (TNF) signalling. However, little is known about the regulatory mechanisms of linear ubiquitination, except the well-described enzymatic regulators E3 ligase linear ubiquitin chain assembly complex (LUBAC) and deubiquitinase OTULIN.Previously, we identified SNX27, a member of the sorting nexin family ... [more]
Cell Biosci Jul. 27, 2021; 11(1);146 [Pubmed: 34315543]
Throughput
- High Throughput
Additional Notes
- Affinity Capture-MS was carried out to identify high confidence protein-protein interactors with a fold change of >2 over control and an adjusted p<0.05
Curated By
- BioGRID