BAIT
RNF43
RNF124, URCC
ring finger protein 43
GO Process (5)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ANK3
ANKYRIN-G, MRT37, RP11-369L1.1
ankyrin 3, node of Ranvier (ankyrin G)
GO Process (17)
GO Function (7)
GO Component (14)
Gene Ontology Biological Process
- Golgi to plasma membrane protein transport [IMP]
- axonogenesis [ISS]
- cytoskeletal anchoring at plasma membrane [TAS]
- establishment of protein localization [IMP]
- maintenance of protein location in plasma membrane [IGI]
- membrane assembly [IMP]
- mitotic cytokinesis [IMP]
- neuronal action potential [ISS]
- plasma membrane organization [IMP]
- positive regulation of gene expression [ISS]
- positive regulation of membrane depolarization during cardiac muscle cell action potential [ISS]
- positive regulation of membrane potential [ISS]
- positive regulation of sodium ion transmembrane transporter activity [ISS]
- positive regulation of sodium ion transport [ISS]
- protein localization to plasma membrane [IGI, IMP]
- protein targeting to plasma membrane [IMP]
- regulation of potassium ion transport [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- T-tubule [ISS]
- axon initial segment [ISS]
- basal plasma membrane [IDA]
- basolateral plasma membrane [IDA]
- cell surface [ISS]
- costamere [TAS]
- endoplasmic reticulum [TAS]
- intercalated disc [ISS]
- lateral plasma membrane [IDA]
- node of Ranvier [ISS]
- plasma membrane [ISS]
- sarcolemma [IDA]
- spectrin-associated cytoskeleton [ISS]
- tight junction [IDA]
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.
RNF43 is an E3 ubiquitin ligase and known negative regulator of WNT/?-catenin signaling. We demonstrate that RNF43 is also a regulator of noncanonical WNT5A-induced signaling in human cells. Analysis of the RNF43 interactome using BioID and immunoprecipitation showed that RNF43 can interact with the core receptor complex components dedicated to the noncanonical Wnt pathway such as ROR1, ROR2, VANGL1, and ... [more]
Elife Dec. 27, 2020; 10(); [Pubmed: 34702444]
Throughput
- Low Throughput
Additional Notes
- BioID
Curated By
- BioGRID