BAIT

ATG9A

APG9L1, MGD3208, mATG9

autophagy related 9A

Autophagy Project

GO Process (5)

GO Function (1)

GO Component (9)

Gene Ontology Biological Process

autophagic vacuole assembly [IMP]

late nucleophagy [IBA]

mitochondrion degradation [IBA]

piecemeal microautophagy of nucleus [IBA]

protein localization to pre-autophagosomal structure [IBA]

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

autophagic vacuole [IBA]

autophagic vacuole membrane [IDA]

integral component of membrane [IBA]

late endosome [IDA]

pre-autophagosomal structure [IBA, IDA]

recycling endosome [IDA]

trans-Golgi network [IDA]

CRISPR Database HGNC Alliance of Genome Resources VEGA OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

APPL1

APPL, DIP13alpha

adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1

GO Process (8)

GO Function (3)

GO Component (7)

Gene Ontology Biological Process

apoptotic process [TAS]

cell proliferation [IDA]

insulin receptor signaling pathway [TAS]

positive regulation of apoptotic process [TAS]

regulation of apoptotic process [TAS]

regulation of establishment of protein localization to plasma membrane [IMP]

regulation of glucose import [IMP]

signal transduction [TAS]

Gene Ontology Molecular Function

identical protein binding [IPI]
protein binding [IPI]
protein kinase B binding [IPI]

Gene Ontology Cellular Component

NuRD complex [IDA]

endosome membrane [IDA, TAS]

extracellular vesicular exosome [IDA]

vesicle membrane [IDA]

CRISPR Database OMIM VEGA HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Proximity Label-MS

An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.

Publication

BioID reveals an ATG9A interaction with ATG13-ATG101 in the degradation of p62/SQSTM1-ubiquitin clusters.

Kannangara AR, Poole DM, McEwan CM, Youngs JC, Weerasekara VK, Thornock AM, Lazaro MT, Balasooriya ER, Oh LM, Soderblom EJ, Lee JJ, Simmons DL, Andersen JL

ATG9A, the only multi-pass transmembrane protein among core ATG proteins, is an essential regulator of autophagy, yet its regulatory mechanisms and network of interactions are poorly understood. Through quantitative BioID proteomics, we identify a network of ATG9A interactions that includes members of the ULK1 complex and regulators of membrane fusion and vesicle trafficking, including the TRAPP, EARP, GARP, exocyst, AP-1, ... [more]

EMBO Rep Dec. 05, 2020; 22(10);e51136 [Pubmed: 34369648]

Throughput

High Throughput

Curated By

BioGRID