BAIT

ATG9A

APG9L1, MGD3208, mATG9

autophagy related 9A

Autophagy Project

GO Process (5)

GO Function (1)

GO Component (9)

Gene Ontology Biological Process

autophagic vacuole assembly [IMP]

late nucleophagy [IBA]

mitochondrion degradation [IBA]

piecemeal microautophagy of nucleus [IBA]

protein localization to pre-autophagosomal structure [IBA]

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

autophagic vacuole [IBA]

autophagic vacuole membrane [IDA]

integral component of membrane [IBA]

late endosome [IDA]

pre-autophagosomal structure [IBA, IDA]

recycling endosome [IDA]

trans-Golgi network [IDA]

CRISPR Database HGNC Alliance of Genome Resources VEGA OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

PTPN1

PTP1B

protein tyrosine phosphatase, non-receptor type 1

Alzheimer's Disease Project

GO Process (19)

GO Function (8)

GO Component (5)

Gene Ontology Biological Process

JAK-STAT cascade involved in growth hormone signaling pathway [TAS]

actin cytoskeleton reorganization [IMP]

blood coagulation [TAS]

cytokine-mediated signaling pathway [TAS]

endoplasmic reticulum unfolded protein response [IDA]

interferon-gamma-mediated signaling pathway [TAS]

negative regulation of ERK1 and ERK2 cascade [ISS]

negative regulation of insulin receptor signaling pathway [NAS]

negative regulation of vascular endothelial growth factor receptor signaling pathway [ISS]

peptidyl-tyrosine dephosphorylation [IDA, IMP]

peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity [ISS]

platelet activation [TAS]

platelet-derived growth factor receptor-beta signaling pathway [IMP]

regulation of endocytosis [IDA]

regulation of hepatocyte growth factor receptor signaling pathway [IMP]

regulation of interferon-gamma-mediated signaling pathway [TAS]

regulation of signal transduction [IMP]

regulation of type I interferon-mediated signaling pathway [TAS]

type I interferon signaling pathway [TAS]

Gene Ontology Molecular Function

enzyme binding [IPI]
ephrin receptor binding [IPI]
poly(A) RNA binding [IDA]
protein binding [IPI]
protein kinase binding [IPI]
protein tyrosine phosphatase activity [IDA, TAS]
receptor tyrosine kinase binding [IPI]
zinc ion binding [IDA]

Gene Ontology Cellular Component

early endosome [IDA]

endoplasmic reticulum [IDA]

plasma membrane [IDA]

sorting endosome [ISS]

CRISPR Database OMIM HGNC Alliance of Genome Resources VEGA Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Proximity Label-MS

An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.

Publication

BioID reveals an ATG9A interaction with ATG13-ATG101 in the degradation of p62/SQSTM1-ubiquitin clusters.

Kannangara AR, Poole DM, McEwan CM, Youngs JC, Weerasekara VK, Thornock AM, Lazaro MT, Balasooriya ER, Oh LM, Soderblom EJ, Lee JJ, Simmons DL, Andersen JL

ATG9A, the only multi-pass transmembrane protein among core ATG proteins, is an essential regulator of autophagy, yet its regulatory mechanisms and network of interactions are poorly understood. Through quantitative BioID proteomics, we identify a network of ATG9A interactions that includes members of the ULK1 complex and regulators of membrane fusion and vesicle trafficking, including the TRAPP, EARP, GARP, exocyst, AP-1, ... [more]

EMBO Rep Dec. 05, 2020; 22(10);e51136 [Pubmed: 34369648]

Throughput

High Throughput

Curated By

BioGRID