BAIT

TRIM11

BIA1, RNF92

tripartite motif containing 11

GO Process (5)

GO Function (1)

GO Component (1)

Gene Ontology Biological Process

innate immune response [IMP]

negative regulation of viral entry into host cell [IMP]

negative regulation of viral release from host cell [IDA, IMP]

negative regulation of viral transcription [IDA]

positive regulation of viral entry into host cell [IMP]

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

cytoplasm [IDA]

CRISPR Database OMIM HGNC Alliance of Genome Resources VEGA Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

AGO2

EIF2C2, Q10

argonaute RISC catalytic component 2

GO Process (18)

GO Function (7)

GO Component (9)

Gene Ontology Biological Process

Fc-epsilon receptor signaling pathway [TAS]

Notch signaling pathway [TAS]

RNA phosphodiester bond hydrolysis, endonucleolytic [EXP, IDA]

epidermal growth factor receptor signaling pathway [TAS]

fibroblast growth factor receptor signaling pathway [TAS]

gene expression [TAS]

gene silencing by RNA [ISS]

innate immune response [TAS]

mRNA cleavage involved in gene silencing by miRNA [IDA, IMP]

negative regulation of translation involved in gene silencing by miRNA [IDA, IMP]

negative regulation of translational initiation [IDA]

neurotrophin TRK receptor signaling pathway [TAS]

phosphatidylinositol-mediated signaling [TAS]

positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [ISS]

positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [ISS]

pre-miRNA processing [IDA]

translation [NAS]

translational initiation [NAS]

Gene Ontology Molecular Function

RNA 7-methylguanosine cap binding [IDA]
endoribonuclease activity [EXP]
endoribonuclease activity, cleaving siRNA-paired mRNA [IDA]
poly(A) RNA binding [IDA]
protein binding [IPI]
siRNA binding [IDA]
translation initiation factor activity [NAS]

Gene Ontology Cellular Component

RISC complex [IDA]

cytoplasm [IDA]

cytoplasmic mRNA processing body [IDA]

mRNA cap binding complex [IDA]

micro-ribonucleoprotein complex [IDA]

ribonucleoprotein complex [IDA]

CRISPR Database OMIM VEGA HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Tripartite motif-containing protein 11 promotes hepatocellular carcinogenesis through ubiquitin-proteasome-mediated degradation of pleckstrin homology domain leucine-rich repeats protein phosphatase 1.

Yang J, Ye J, Ma T, Tang F, Huang L, Liu Z, Tian S, Cheng X, Zhang L, Guo Z, Tu F, He M, Xu X, Lu X, Wu Y, Zeng X, Zou J, Wang X, Peng W, Zhang P

HCC is one of the main types of primary liver cancer, with high morbidity and mortality and poor treatment effect. Tripartite motif-containing protein 11 (TRIM11) has been shown to promote tumor formation in lung cancer, breast cancer, gastric cancer, and so on. However, the specific function and mechanism of TRIM11 in HCC remain open for study.Through clinical analysis, we found ... [more]

Hepatology Nov. 12, 2021; (); [Pubmed: 34767673]

Throughput

High Throughput

Curated By

BioGRID