BAIT
SOX2
ANOP3, MCOPS3
SRY (sex determining region Y)-box 2
GO Process (23)
GO Function (6)
GO Component (5)
Gene Ontology Biological Process
- cell cycle arrest [IDA]
- chromatin organization [NAS]
- endodermal cell fate specification [IDA]
- eye development [IEP]
- forebrain development [IEP]
- glial cell fate commitment [NAS]
- inner ear development [IEP]
- negative regulation of canonical Wnt signaling pathway [IDA]
- negative regulation of epithelial cell proliferation [IDA]
- negative regulation of neuron differentiation [ISS]
- negative regulation of transcription from RNA polymerase II promoter [ISS]
- neuronal stem cell maintenance [ISS]
- osteoblast differentiation [IDA]
- pituitary gland development [IEP]
- positive regulation of MAPK cascade [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- regulation of gene expression [IMP]
- regulation of transcription, DNA-templated [IDA, NAS]
- response to growth factor [IDA]
- response to wounding [IEP]
- somatic stem cell maintenance [IDA, IMP]
Gene Ontology Molecular Function
Homo sapiens
PREY
AGO2
EIF2C2, Q10
argonaute RISC catalytic component 2
GO Process (18)
GO Function (7)
GO Component (9)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- Notch signaling pathway [TAS]
- RNA phosphodiester bond hydrolysis, endonucleolytic [EXP, IDA]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- gene expression [TAS]
- gene silencing by RNA [ISS]
- innate immune response [TAS]
- mRNA cleavage involved in gene silencing by miRNA [IDA, IMP]
- negative regulation of translation involved in gene silencing by miRNA [IDA, IMP]
- negative regulation of translational initiation [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [ISS]
- positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [ISS]
- pre-miRNA processing [IDA]
- translation [NAS]
- translational initiation [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma.
The pluripotency transcription factor SOX2 is essential for the maintenance of glioblastoma stem cells (GSC), which are thought to underlie tumor growth, treatment resistance, and recurrence. To understand how SOX2 is regulated in GSCs, we utilized a proteomic approach and identified the E3 ubiquitin ligase TRIM26 as a direct SOX2-interacting protein. Unexpectedly, we found TRIM26 depletion decreased SOX2 protein levels ... [more]
Nat Commun Dec. 03, 2020; 12(1);6321 [Pubmed: 34732716]
Throughput
- Low Throughput
Curated By
- BioGRID