BAIT
TRIM31
C6orf13, HCG1, HCGI, RNF, DAAP-112O13.2
tripartite motif containing 31
GO Process (5)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
PFN2
D3S1319E, PFL
profilin 2
GO Process (8)
GO Function (4)
GO Component (1)
Gene Ontology Biological Process
- negative regulation of actin filament polymerization [IDA]
- negative regulation of epithelial cell migration [IMP]
- negative regulation of ruffle assembly [IMP]
- positive regulation of ATPase activity [IDA]
- positive regulation of actin filament bundle assembly [IMP]
- positive regulation of actin filament polymerization [IGI]
- positive regulation of peptidyl-serine phosphorylation [IMP]
- positive regulation of stress fiber assembly [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Loss of TRIM31 promotes breast cancer progression through regulating K48- and K63-linked ubiquitination of p53.
Breast cancer is the most common cancer in the world. Relapse and metastasis are important factors endangering the life of breast cancer patients, but the mechanism is still unclear. The stabilization of p53 is essential for preventing carcinogenesis, and ubiquitination is one of the main ways to regulate the stability of p53. Tripartite motif-containing 31 (TRIM31) is a new member ... [more]
Cell Death Dis Dec. 14, 2020; 12(10);945 [Pubmed: 34650049]
Throughput
- Low Throughput
Curated By
- BioGRID