TERT
Gene Ontology Biological Process
- DNA strand elongation [IDA]
- age-dependent telomere shortening [IBA]
- mitochondrion organization [IDA]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- positive regulation of Wnt signaling pathway [IGI]
- replicative senescence [IMP]
- telomere formation via telomerase [IDA]
- telomere maintenance [TAS]
- telomere maintenance via telomerase [IMP, NAS, TAS]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA-directed DNA polymerase activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- tRNA binding [IDA]
- telomerase activity [IDA]
- telomeric DNA binding [TAS]
- telomeric RNA binding [IDA]
- telomeric template RNA reverse transcriptase activity [IDA, TAS]
- transcription coactivator binding [IPI]
- DNA binding [IDA]
- RNA-directed DNA polymerase activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- tRNA binding [IDA]
- telomerase activity [IDA]
- telomeric DNA binding [TAS]
- telomeric RNA binding [IDA]
- telomeric template RNA reverse transcriptase activity [IDA, TAS]
- transcription coactivator binding [IPI]
Gene Ontology Cellular Component
UPF1
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- DNA repair [IDA]
- DNA replication [IMP]
- RNA metabolic process [TAS]
- gene expression [TAS]
- histone mRNA catabolic process [IMP]
- mRNA export from nucleus [TAS]
- mRNA metabolic process [TAS]
- nuclear-transcribed mRNA catabolic process [IMP]
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [IDA, IMP, NAS, TAS]
- regulation of translational termination [IMP, NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication.
Eukaryotic up-frameshift 1 (UPF1) is a nucleic acid-dependent ATPase and 5'-to-3' helicase, best characterized for its roles in cytoplasmic RNA quality control. We previously demonstrated that human UPF1 binds to telomeres in vivo and its depletion leads to telomere instability. Here, we show that UPF1 is present at telomeres at least during S and G2/M phases and that UPF1 association ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| UPF1 TERT | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID